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EC50
From Wikipedia, the free encyclopedia
The term EC50 is the concentration of a drug which induces a response halfway between the baseline and maximum.[1] It is commonly used as a measure of drug potency.
The EC50 of a graded dose response curve therefore represents the concentration of a compound where 50% of its maximal effect is observed[2]. The EC50 or a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a response[3].
It is also related to IC50 which is a measure of a compound's inhibition (50% inhibition).
According to the FDA, IC50 represents the concentration of a drug that is required for 50% inhibition in vitro whereas EC50 represents the plasma concentration required for obtaining 50% of a maximum effect in vivo.[4]
Concentration measures typically follow an S-shaped curve, increasing rapidly over a relatively small change in concentration. The point at which the effectiveness slows with increasing concentration is the IC50. This can be determined mathematically by derivation of the best-fit line. However, it is more easily observed from a graph and estimated rather than through complex calculus equations.
- ^ Introducing doseresponse curves, Graphpad Software]
- ^ EC50 definition
- ^ definition of EC50 for quantal dose response curve
- ^ [1],FDA
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