5-Lipoxygenase activating protein

From Wikipedia, the free encyclopedia

arachidonate 5-lipoxygenase-activating protein
Identifiers
Symbol ALOX5AP
HUGO 436
Entrez 241
OMIM 603700
RefSeq NM_001629
UniProt P20292
Other data
Locus Chr. 13 q12

5-Lipoxygenase activating protein, or FLAP, is an enzyme necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes. It is bound to the nuclear membrane. Gene polymorphisms in FLAP are suspected of playing a role in Alzheimer's disease.[1]

  1. ↑  Manev H, Manev R.. 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease.. Med Hypotheses. 2006;66(3):501-3.. Retrieved on 2006-03-02. PubMed citation.


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