Abl gene

From Wikipedia, the free encyclopedia

v-abl Abelson murine leukemia viral oncogene homolog 1
Identifiers
Symbol ABL1 ABL
HUGO 76
Entrez 25
OMIM 189980
RefSeq NM_007313
UniProt P00519
Other data
Locus Chr. 9 q34.1

The abl gene is associated with chronic myelogenous leukemia. The abl gene is located on the 9th chromosome. This gene is activated by being translocated within the bcr (breakpoint cluster region) gene on chromosome 22. This new abl/bcr (chimeric) gene encodes a tyrosine kinase which allows the cells to proliferate without being regulated by cytokines. This in turn allows the cell to become cancerous.

  • Dunitz, Martin. "Chronic Myeloid Leukaemia" 2001. Taylor & Francis, Limited. Published online via Ebrary.com

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