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Lady Amanda Grayson is a fictional character in the Star Trek universe. She is the human mother of Mr. Spock.

Little is known about Amanda. She appeared in only one episode of Star Trek: The Original Series ("Journey to Babel") and two movies: Star Trek IV: The Voyage Home, and briefly in Star Trek V: The Final Frontier. Her surname is not mentioned in "Journey to Babel" or in the movies, even though it was given to her in an early draft of the screenplay of "Journey to Babel". She is first mentioned as Amanda Grayson in the animated series episode "Yesteryear", which is not considered official canon. She is a very popular character and appears in many Star Trek novels and fan fiction stories, and to date her accepted last name has not been contradicted by any film or TV episode. In "Journey to Babel", she states that she has a Vulcan name which she has learned to pronounce after a fashion, but asks to be addressed by her human first name.

In Star Trek VI: The Undiscovered Country, Spock makes a comment he attributes to one of his ancestors. It is a quote from Sherlock Holmes, which implies that Amanda is a descendant of Arthur Conan Doyle. Some fans have speculated that she is instead a descendant of the detective, but because Sherlock Holmes is established as being a fictional character in the Star Trek universe in a Star Trek: The Next Generation episode, that seems unlikely. It has also been suggested that the film is temporarily "breaking the fourth wall," as the character of Spock is often believed to have been partly inspired by the character of Sherlock Holmes.

According to the most accepted Star Trek chronology, Amanda Grayson was born in 2202 in Seattle, Washington. She met Ambassador Sarek, a member of a prominent Vulcan family, in 2223. They married in the same year and she moved to Vulcan with her husband. Although it wasn't mentioned in the series, their marriage is usually considered to be the first marriage between two species. Spock is the first generally known Vulcan-Human hybrid, although decades before his birth an Earth splinter group - Terra Prime - had briefly created a Vulcan-Human child from the DNA of Charles 'Trip' Tucker and T'Pol in an attempt to win support for its cause. Spock is the first such hybrid to live a normal lifespan; Trip and T'Pol's child, Elizabeth had died shortly after birth because of genetic defects.

In "Journey To Babel" and The Voyage Home, Amanda was played by Jane Wyatt. Another actress, Cynthia Blaise, played Amanda in the flashback scene of The Final Frontier, and Majel Barrett was the voice of Amanda in the animated series, but the role of Amanda is almost always associated with Jane Wyatt.

At some point between 2286 and 2366 (after the events of Star Trek IV and Star Trek: The Next Generation episode, Sarek,) Amanda had died. Sarek eventually married another human woman, Perrin.

At the very end of Barbara Hambly's Star Trek novel Ishmael — a tie-in to the television series Here Come the Brides — Amanda Grayson is revealed to be a descendant of Brides character Aaron Stempel.

• Amanda Grayson article at Memory Alpha, a Star Trek wiki.
• The Amanda Grayson Tribute Page -- a fanpage with pictures, dedicated to the character Amanda Grayson and actress Jane Wyatt
• Jane Wyatt at the Internet Movie Database