Angiotensin-converting enzyme 2

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Angiotensin I converting enzyme 2
Identifiers
Symbol ACE2 ACEH
HUGO 13557
Entrez 59272
OMIM 300335
RefSeq NM_021804
UniProt Q9BYF1
Other data
Locus Chr. X p22

Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9] [1]. ACE 2 has direct effects on cardiac function[2], and is expressed predominantly in vascular endothelial cells of the heart and the kidneys [1].


  1. a  b  Image:Free_text.png Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 2000;87:E1-9. PubMed Free text
  2. a  Boehm M, Nabel EG. Angiotensin-converting enzyme 2--a new cardiac regulator. N Engl J Med 2002;347:1795-7. PubMed


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