Apraclonidine

From Wikipedia, the free encyclopedia

Apraclonidine
Systematic (IUPAC) name
2,6-dichloro-N- (4,5-dihydro-1H-imidazol-2-yl) benzene-1,4-diamine
Identifiers
CAS number 66711-21-5
ATC code S01EA03
PubChem 2216
DrugBank APRD00012
Chemical data
Formula C9H10Cl2N4 
Mol. mass 245.108 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 98.7%
Metabolism  ?
Half life 8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Apraclonidine is a sympathomimetic used in glaucoma therapy.

  • Chen P, Chen J, Lu D, Chen Y, Hsiao C (2006). "Comparing efficacies of 0.5% apraclonidine with 4% cocaine in the diagnosis of horner syndrome in pediatric patients.". J Ocul Pharmacol Ther 22 (3): 182-7. PMID 16808679. 
  • Aslanides l, Tsiklis N, Ozkilic E, Coskunseven E, Pallikaris l, Jankov M (2006). "The effect of topical apraclonidine on subconjunctival hemorrhage and flap adherence in LASIK patients.". J Refract Surg 22 (6): 585-8. PMID 16805122. 
  • Koc F, Kansu T, Kavuncu S, Firat E (2006). "Topical apraclonidine testing discloses pupillary sympathetic denervation in diabetic patients.". J Neuroophthalmol 26 (1): 25-9. PMID 16518162. 
  • Garibaldi D, Hindman H, Grant M, Iliff N, Merbs S. "Effect of 0.5% apraclonidine on ptosis in Horner syndrome.". Ophthal Plast Reconstr Surg 22 (1): 53-5. PMID 16418668. 
  • Onal S, Gozum N, Gucukoglu A. "Effect of apraclonidine versus dorzolamide on intraocular pressure after phacoemulsification.". Ophthalmic Surg Lasers Imaging 36 (6): 457-62. PMID 16355950. 
v • d • e
Antiglaucoma preparations and miotics (S01E)
Sympathomimetics Apraclonidine, Brimonidine, Clonidine, Dipivefrine, Epinephrine
Parasympathomimetics Aceclidine, Acetylcholine, Carbachol, Demecarium, Echothiophate, Fluostigmine, Neostigmine, Paraoxon, Physostigmine, Pilocarpine
Carbonic anhydrase inhibitors Acetazolamide, Brinzolamide, Diclofenamide, Dorzolamide, Methazolamide
Beta blocking agents Befunolol, Betaxolol, Carteolol, Levobunolol, Metipranolol, Timolol
Prostaglandin analogues Bimatoprost, Latanoprost, Travoprost, Unoprostone
Other agents Dapiprazole, Guanethidine


Pills  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org../../../a/p/r/Apraclonidine.html"
Advanced Search
Included Web Search Engines


Safe Search

close

Top Matching Results

Occasionally Search.com will highlight specialized results that are based on the context of your query. Examples of specialized results include specific links to news, images, or video.

Top Matching Results may highlight information from other Search.com pages, content from the CNET Network of sites, or third party content. The listings are based purely on relevance. Search.com does not receive payment for listings in this section but our partners that provide this data may get paid for listing these products.

Sponsored Links

This section contains paid listings which have been purchased by companies that want to have their sites appear for specific search terms and related content. These listings are administered, sorted and maintained by a third party and are not endorsed by Search.com.

Search Results

Search.com sends your search query to several search engines at one time and integrates the results into one list which has been sorted by relevance using Search.com's proprietary algorithm. You can customize the list of search engines included in your metasearch from the preferences.

The search engines that are used in your metasearch may allow companies to pay to have their Web sites included within the results. To view the Paid Inclusion policy for a specific search engine, please visit their Web site. Search.com does not accept payment or share revenue with any search engine partner for listings in this section.