Aquaporin 4
From Wikipedia, the free encyclopedia
|
aquaporin 4
|
|
| Identifiers | |
| Symbol | AQP4 |
| HUGO | 637 |
| Entrez | 361 |
| OMIM | 600308 |
| RefSeq | NM_001650 |
| UniProt | P55087 |
| Other data | |
| Locus | Chr. 18 q11.2-12.1 |
Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells.
AQP4 is constitutively expressed.
AQP4 is expressed in astrocytes and are upregulated by direct insult to the central nervous system.
Stretch-activated ion channel - Ligand-gated ion channel - Voltage-gated ion channel
Ca: Voltage-dependent calcium channel (L-type/CACNA1C, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm
Na: Sodium channel: SCN4A - SCN5A - SCN9A - Epithelial sodium channel /Amiloride-sensitive sodium channel
K: Potassium channel: Voltage-gated (KvLQT1, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel) - Inward-rectifier (ROMK, KCNJ2) - Tandem pore domain/Resting ion channel
Cl: Chloride channel: Cystic fibrosis transmembrane conductance regulator
Transient receptor potential (TRPV6) - Cyclic nucleotide-gated ion channel - Two-pore channel