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Astrochemistry is the study of the chemical elements found in outer space, generally on larger scales than the Solar System, particularly in molecular gas clouds, and the study of their formation, interaction and destruction. As such, it represents an overlap of the disciplines of astronomy and chemistry. On the Solar System scale, the study of chemical elements is usually called cosmochemistry.

Astrochemistry involves the use of telescopes to measure various aspects of bodies in space, such as their temperature and composition. Findings from the use of spectroscopy in chemistry laboratories can be employed in determining the types of molecules in astronomical bodies (e.g. a star or an interstellar cloud). The various characteristics of molecules reveal themselves in their spectra, yielding a unique spectral representation corresponding for a molecule. However, there are limitations on measurements due to electromagnetic interference and, more problematic, the chemical properties of some molecules. For example, the most common molecule (H₂, hydrogen gas), does not have a dipole moment, so it is not detected by radio telescopes. Much easier to detect with radio waves, due to its strong electric dipole moment, is CO (carbon monoxide). Over a hundred molecules (including radicals and ions) have been reported so far, including a wide variety of organic compounds, such as alcohols, acids, aldehydes, and ketones. There have been claims regarding interstellar glycine, the simplest amino acid, but with considerable accompanying controversy. Research is progressing on the way interstellar and circumstellar molecules form and interact, and this research could have a profound impact on our understanding of the origin of life on earth.

The sparseness of interstellar and interplanetary space results in some unusual chemistry, since symmetry-forbidden reactions cannot occur except on the longest of timescales. For this reason, molecules and molecular ions which are unstable on Earth can be highly abundant in space, for example the H₃⁺ ion.

Astrochemistry overlaps strongly^{[citation needed]} with astrophysics and nuclear physics in characterizing the nuclear reactions which occur in stars, the consequences for stellar evolution, as well as stellar 'generations'. Indeed, the nuclear reactions in stars produce every naturally-occurring chemical element. As the stellar 'generations' advance, the mass of the newly-formed elements increases. A first-generation star uses elemental hydrogen (H) as a fuel source and produces helium (He). Hydrogen is the most abundant element, and it is the basic building block for all other elements as its nucleus has only one proton. Gravitational pull toward the center of a star creates massive amounts of heat and pressure, which cause nuclear fusion. Through this process of merging nuclear mass, heavier elements are formed. Lithium, carbon, nitrogen and oxygen are examples of elements that form in stellar fusion. After many stellar generations, very heavy elements are formed (e.g. iron and lead).

• Interstellar cloud
• Interstellar medium
• List of molecules in interstellar space
• Nebula
• Molecular astrophysics
• Back-contamination
• Fermi paradox
• Forward-contamination
• Human evolution
• Origin of life
• Star Jelly
• Timeline of the Big Bang
• Anthropic principle
• Biogenesis
• Drake equation
• Fine-tuned universe
• Important publications in origin of life
• Origin belief
• Planetary habitability
• Panspermia
• Chemical evolution

• Astrochemistry division of the International Astronomical Union