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Benfotiamine
From Wikipedia, the free encyclopedia
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Benfotiamine
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| Systematic (IUPAC) name | |
| S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl- formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate |
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| Identifiers | |
| CAS number | |
| ATC code | A11 |
| PubChem | |
| Chemical data | |
| Formula | C19H23N4O6PS |
| Mol. mass | 466.449 g/mol |
| Synonyms | S-benzoylthiamine-O-monophosphate |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Benfotiamine (rINN, also known as benfotiamine or benphothiamine) is an allithiamin, a naturally-occurring lipophilic form of thiamine. The primary use of this antioxidant is as an "anti-age" supplement. However, in Germany doctors have been known to combine benfotiamine with pyridoxine hydrochloride and use it to treat patients with nerve damage and nerve pain such as sciatica.
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| fat soluble | A (Retinol, Beta-carotene) - D (Ergocalciferol, Cholecalciferol, Dihydrotachysterol, Calcitriol, Calcidiol) - E (Tocopherol) - K (Naphthoquinone) |
| water soluble: B vitamins | B1 (Thiamine, Sulbutiamine, Benfotiamine) - B2 (Riboflavin) - B3 (Niacin, Nicotinamide) - B5 (Pantothenic acid, Dexpanthenol, Pantethine) - B6 (Pyridoxine, Pyridoxal phosphate) - B7 (Biotin) - B9 (Folic acid) - B12 (Cyanocobalamin, Hydroxocobalamin, Mecobalamin) |
| water soluble: other | C (Ascorbic acid) - Choline |
Benfotiamine has shown to be an effective intervention for the treatment of diabetic retinopathy, neuropathy, and nephropathy, possibly because Benfotiamine is a transketolase activator that directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway, thus reducing tissue AGEs.