Bone morphogenetic protein 8b

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Bone morphogenetic protein 8b
Other names: Osteogenic Protein 2 (OP2)
Genetic data
Locus: Chr. 1 p35-p32
Gene code: HUGO code:BMP8b
Protein Structure/Function
Functions: cell signaling, cell differentiation,cartilage development, growth, ossification
Domains: TGFβ
Other
Taxa expressing: many metazoan phyla
Cell types: many (hippocampus)
Subcellular localization: extracellular
Database Links
Entrez: 656
OMIM: 602284
RefSeq: NM_001720
UniProt: P34820

Bone morphogenetic protein 8b (BMP8b) is a polypeptide belonging to the TGF-β superfamily of proteins. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murine embryos.



v • d • e
Cell signaling: TGF beta signaling pathway
TGF beta superfamily of ligands TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15)
Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15)
Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal)
TGF beta receptors TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B)
TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2
TGFBR3: betaglycan
Transducers/SMAD R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
Coreceptors BAMBI - Cripto
Other SARA
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Retrieved from "http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_8b"
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