Booster dose

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After initial immunization, a booster injection or Booster dose is essentially a reexposure to the immunizing antigen. It is intended to increase your immunity against that antigen back to protective levels after it has been shown to have decreased or after a specified period of time (eg tetanus shot boosters every 10 years).

If you receive a booster and already have high antibody titers you may develop a reaction called an Arthus reaction, a localized form of Type III hypersensitivity, induced by fixation of complement by preformed circulating antibodies. In severe cases, the degree of complement fixation can be so substantial that it induces local tissue necrosis.


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