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CYP1A2
From Wikipedia, the free encyclopedia
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cytochrome P450, family 1, subfamily A, polypeptide 2
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| Identifiers | |
| Symbol | CYP1A2 |
| HUGO | 2596 |
| Entrez | 1544 |
| OMIM | 124060 |
| RefSeq | NM_000761 |
| UniProt | P05177 |
| Other data | |
| EC number | 1.14.14.1 |
| Locus | Chr. 15 q24.1 |
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.
Expression of CYP1A2 appears to be induced by various dietary constituents.[1]
| Selected inducers, inhibitors and substrates of CYP1A21 | |
| Type | Agent |
| inducers | broccoli, brussel sprouts, chargrilled meat, insulin, modafinil, nafcillin, omeprazole, tobacco, hyperforin (constituent of St Johns Wort) |
| inhibitors | amiodarone, cimetidine, fluoroquinolones (ciprofloxacin, etc), fluvoxamine, interferon, methoxsalen |
| substrates | amitriptyline, caffeine, clomipramine, clozapine, cyclobenzaprine, estradiol, fluvoxamine, haloperidol, imipramine, mexiletine, naproxen, olanzapine, ondansetron, paracetamol, propranolol, riluzole, ropivacaine, tacrine, theophylline, tizanidine, verapamil, warfarin, zileuton, zolmitriptan |
Notes:
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- ^ Fontana R, Lown K, Paine M, Fortlage L, Santella R, Felton J, Knize M, Greenberg A, Watkins P (1999). "Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers". Gastroenterology 117 (1): 89-98. PMID 10381914.
- Meijerman I, Beijnen J, Schellens J. "Herb-drug interactions in oncology: focus on mechanisms of induction". Oncologist 11 (7): 742-52. PMID 16880233.