CYP2E1

From Wikipedia, the free encyclopedia

Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.14.1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are some important drug interactions mediated by CYP2E1.

Selected inducers, inhibitors and substrates of CYP2E11
Type Agent
inducers acetone, ethanol, isoniazid
inhibitors cimetidine, disulfiram, (isoniazid)?
substrates anaesthetics (halothane, isoflurane, etc), dapsone, paracetamol (acetaminophen), theophylline
Notes:
  1. Where classes of agents are listed, there may be exceptions within the class.


cytochrome P450, family 2, subfamily E, polypeptide 1
Identifiers
Symbol CYP2E1 CYP2E
HUGO 2631
Entrez 1571
OMIM 124040
RefSeq NM_000773
UniProt P05181
Other data
Locus Chr. 10 q24.3-qter

v • d • e
Oxidoreductases: oxygenases (EC 1.13, 14)

Monooxygenases: 4-Hydroxyphenylpyruvate dioxygenase - Firefly luciferase

Dioxygenases: Aromatase - Nitric oxide synthase - CYP2D6 - CYP2E1 - CYP3A4 - Phenylalanine hydroxylase - Tryptophan hydroxylase - Tyrosine hydroxylase - Dopamine beta hydroxylase - Tyrosinase - Steroid hydroxylases

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