Chlortalidone

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Chlortalidone
Systematic (IUPAC) name
2-chloro-5-(1-hydroxy-3-oxo-1,2-dihydroisoindol-1-yl)- benzenesulfonamide
Identifiers
CAS number 77-36-1
ATC code C03BA04
PubChem 2732
DrugBank APRD00127
Chemical data
Formula C14H11ClN2O4S 
Mol. mass 338.767 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 75%
Metabolism  ?
Half life 40 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C (Au), B (U.S.)
Legal status

POM (UK)
Routes Oral

Chlortalidone (formerly spelled chlorthalidone in the UK) is a thiazide diuretic, used to treat hypertension.

It is also available in the UK as a combination product with the beta blocker atenolol as Co-tenidone.


Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Antihypertensives (C02) and diuretics (C03)
Antiadrenergic agents (including alpha) centrally acting (Clonidine, Guanfacine, Methyldopa, Moxonidine, Rescinnamine, Reserpine, Rilmenidine) • ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) • peripherally acting (Prazosin, Guanethidine, Indoramin, Doxazosin)
Vasodilators Diazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensives serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan)
Low ceiling diuretics Thiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine
High ceiling diuretics Loop diuretic (Bumetanide, Furosemide, Torasemide)
Potassium-sparing diuretics ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)
Retrieved from "http://en.wikipedia.org/wiki/Chlortalidone"
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