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Clenbuterol
From Wikipedia, the free encyclopedia
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Clenbuterol
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| Systematic (IUPAC) name | |
| 1-(4-amino-3,5-dichloro-phenyl)- 2-(tert-butylamino)ethanol |
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| Identifiers | |
| CAS number | |
| ATC code | R03 R03CC13 |
| PubChem | |
| Chemical data | |
| Formula | C12H18Cl2N2O |
| Mol. mass | 277.19 |
| Pharmacokinetic data | |
| Bioavailability | 89-98% orally |
| Metabolism | ? |
| Half life | 36 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
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| Routes | oral |
Clenbuterol is a drug prescribed to sufferers of breathing disorders as a decongestant and bronchodilator. People with chronic breathing disorders like asthma use this as a bronchodilator to make breathing easier. It is most commonly available in salt form as Clenbuterol hydrochloride. Clenbuterol is often mistaken for a steroid because of its illicit use in athletics.
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Clenbuterol is a β2 adrenergic agonist with some similarities to ephedrine, but its effects are more potent and longer-lasting as a stimulant and thermogenic drug. It causes an increase in aerobic capacity, CNS stimulation, and an increase in blood pressure and oxygen transportation. It increases the rate at which fat and protein is used up in the body at the same time as slowing down the storage of glycogen. It is commonly used for smooth muscle relaxant properties. These mean that it is a bronchodilator, and tocolytic. It is usually used in dosages of 20 micrograms.
Clenbuterol is used worldwide for the treatment of allergic respiratory disease in horses as it is a bronchodilator. A common trade name is Ventipulmin. It can be used both orally and intravenously. It is also a non-steroidal anabolic and metabolism accelerator, through a mechanism not well understood. Its ability to induce weight gain and a greater proportion of muscle to fat makes its illegal use in livestock popular.
In September 2006 over 330 people in Shanghai were reported to have been poisoned by eating pork contaminated by Clenbuterol that had been fed to the animals to keep their meat lean.[1]
As of fall, 2006, Clenbuterol is not an ingredient of any therapeutic drug approved by the U.S. Food and Drug Administration. Clenbuterol is now banned for IOC-tested athletes. Jason Grimsley, former Major League baseball pitcher, admitted to using this drug. The tennis player Mariano Puerta was once penalized for use of clenbuterol. Clenbuterol is also used as an unproved slimming aid.[2]
- ^ "Pigs fed on bodybuilder steroids cause food poisoning in Shanghai", AFP, 2006-09-19. Retrieved on 2006-09-19. (in English)
- ^ Daily Mail article
| Medications commonly used in asthma and COPD (primarily R03) | |
|---|---|
| Anticholinergics | Ipratropium, Tiotropium |
| Short acting β2-agonists | Salbutamol, Terbutaline |
| Long acting β2-agonists (LABA) | Bambuterol, Clenbuterol, Fenoterol, Formoterol, Salmeterol |
| Corticosteroids | Beclometasone, Budesonide, Ciclesonide, Fluticasone |
| Leukotriene antagonists | Montelukast, Pranlukast, Zafirlukast |
| Xanthines | Aminophylline, Theobromine, Theophylline |
| Mast cell stabilizers | Cromoglicate, Nedocromil |
| Combination products | Budesonide/formoterol, Fluticasone/salmeterol, Ipratropium/salbutamol |