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Complication, in medicine, is an unfavorable evolution of a disease, a health condition or a medical treatment. The disease can become worse in its severity or show a higher number of signs, symptoms or new pathological changes, become widespread throughout the body or affect other organ systems. A medical treatment, such as drugs or surgery may produce adverse effects and/or produce new health problem(s) by itself. A new disease may also appear as a complication to a previous existing disease. Therefore, a complication may be iatrogenic, i.e., literally brought forth by the physician.

Medical knowledge about a disease, procedure or treatment usually entails a list of the most common complications, so that they can be foreseen, prevented or recognized more easily and speedily.

Depending on the degree of vulnerability, susceptibility, age, health status, immune system condition, etc. complications may arise more easily. Complications affect adversely the prognosis of a disease. Non-invasive and minimally invasive medical procedures usually favor less complications in comparison to invasive ones.

• Generalized septicemia (infection of the blood) may occur as a complication of an infected wound or abscess
• Allergic shock can be a reaction to several kinds of anesthetics, as a complication in a surgery
• Fractured ribs and sternum may be a complication of cardiopulmonary resuscitation attempts in people suffering severe osteoporosis
• Puerperal fever may be a common complication of childbirth and used to kill a large proportion of mothers before the advent of antisepsis and antibiotics
• Diabetes mellitus may present a series of complications in an advanced or more severe stage, such as gangrene, diabetic foot, blindness, infections, etc.
• Thrombosis in the heart or brain, causing stroke or acute myocardial infarction can be complications of blood coagulation disorders, phlebitis (inflammation of the veins), endocarditis and artificial heart valves
• Eczema vaccinatum is a rare and severe complication of smallpox vaccination in people with eczema
• Hepatotoxic dementia is a possible complication of hepatitis and liver cirrhosis
• Mental retardation is a common complication of untreated hydrocephalus
• A paradoxical reaction to a drug that is the totally the opposite effect of the intended purpose of the drug. As in "benzodiazepines" (pronounced [ˌbenzəʊdaɪˈæzəpiːnz], or "benzos" for short) a class of psychoactive drugs considered a minor tranquilizers with varying hypnotic, sedative, anxiolytic, anticonvulsant, and muscle relaxant drug that may create exactly the opposite effect (paradoxical reaction) on susceptible individuals. ^[1]

• Adverse effect (medicine)
• Diagnosis
• Iatrogenesis
• Nocebo
• Placebo (origins of technical term)
• Prognosis