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De Soto is a village in Jackson County, Illinois, United States. The population was 1,653 at the 2000 census.

De Soto was largely destroyed by the Great Tri-State Tornado of 1925. Sixty-nine people died in De Soto when approximately 30% of the town was destroyed, and of this total 33 were children at a local school that collapsed from the winds. The tornado affected Missouri, Illinois, and Indiana killing 695 and injuring over 2,000.

De Soto is located at 37°48′56″N, 89°13′41″W (37.815660, -89.228184)^GR1.

According to the United States Census Bureau, the village has a total area of 2.4 km² (0.9 mi²), all land.

As of the census^GR2 of 2000, there were 1,653 people, 673 households, and 444 families residing in the village. The population density was 679.0/km² (1,752.4/mi²). There were 726 housing units at an average density of 298.2/km² (769.7/mi²). The racial makeup of the village was 97.58% White, 0.73% African American, 0.06% Native American, 0.42% Asian, 0.18% from other races, and 1.03% from two or more races. Hispanic or Latino of any race were 1.57% of the population.

There were 673 households out of which 33.9% had children under the age of 18 living with them, 51.4% were married couples living together, 11.3% had a female householder with no husband present, and 33.9% were non-families. 27.3% of all households were made up of individuals and 9.7% had someone living alone who was 65 years of age or older. The average household size was 2.45 and the average family size was 3.02.

In the village the population was spread out with 26.1% under the age of 18, 10.0% from 18 to 24, 33.3% from 25 to 44, 20.3% from 45 to 64, and 10.2% who were 65 years of age or older. The median age was 33 years. For every 100 females there were 94.5 males. For every 100 females age 18 and over, there were 90.5 males.

The median income for a household in the village was $31,563, and the median income for a family was $34,929. Males had a median income of $30,400 versus $22,632 for females. The per capita income for the village was $15,526. About 10.1% of families and 14.3% of the population were below the poverty line, including 19.7% of those under age 18 and 11.1% of those age 65 or over.

• Maps and aerial photos Coordinates: 37.81566° -89.228184°
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  • Satellite image from Google Maps, Windows Live Local, WikiMapia
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	Municipalities and Communities of Jackson County, Illinois (County Seat: Murphysboro)
Cities, Towns and Villages	Ava | Campbell Hill | Carbondale | De Soto | Dowell | Elkville | Gorham | Grand Tower | Makanda | Murphysboro | Vergennes
Townships	Bradley | Carbondale | Degognia | DeSoto | Elk | Fountain Bluff | Grand Tower | Kinkaid | Levan | Makanda | Murphysboro | Ora | Pomona | Sand Ridge | Somerset | Vergennes
Airports	Southern Illinois Airport