Sources
Help build the largest human-edited directory on the web.
Submit a site - Become an editor
Wikipedia. Licensed under the GNU Free Documentation License.
Are you an expert in this subject? Join the discussion and share your knowledge at Wikipedia.org.
Decorin
From Wikipedia, the free encyclopedia
| Decorin | |
|---|---|
| Symbol(s): | DCN DSPG2, SLRR1B |
| Other names: | Bone proteoglycan II, PG-S2, PG40 |
| Genetic data | |
| Locus: | Chr. 12 q23 |
| Gene code: | HUGO code:DCN |
| Protein Structure/Function | |
| Protein type: | protein coding |
| Functions: | extracellular matrix component, binds TGFβ, fibronectin and collagen type I and II |
| Domains: | LRR |
| Other | |
| Taxa expressing: | Homo Sapiens; homologs: many metazoan phyla |
| Cell types: | many; skin, lung, placenta, kidney, muscle, cartilage, ligament |
| Subcellular localization: | Extracellular |
| Covalent modifications: | Proteolytic Cleavage |
| Medical/Biotechnological data | |
| Diseases: | Congenital stromal corneal dystrophy (CSCD) (Mendelian Inheritance in Man (OMIM) 610048) |
| Database Links | |
| Codes: | EntrezGene 1634; Mendelian Inheritance in Man (OMIM) 125255; RefSeq NM_133507; UniProt P07585 |
Decorin is a proteoglycan on average 90 - 140 kilodaltons (kD) in size. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either Chondroitin Sulfate (CS) or Dermatan Sulfate (DS). Decorin is found in the extracellular matrix. Decorin's name is a derivative of both the fact that it "decorates" collagen, and that it interacts with the "d" and "e" bands. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor EGFR and transforming growth factor-beta (TGF-beta). In some publications, decorin has enhanced the bioactivity of TGF-beta 1, in other publications, TGF-beta 1's bioactivity has been inhibited. Because of this, it is believed the primary function of decorin lies in certain aspects of regulation during the cell cycle.
TGF beta superfamily of ligands:
Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3
Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1
Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
 |
This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |