Diazoxide

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Diazoxide
Systematic (IUPAC) name
7-chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
Identifiers
CAS number 364-98-7
ATC code C02DA01 V03AH01
PubChem 3019
DrugBank APRD00914
Chemical data
Formula C8H7ClN2O2S 
Mol. mass 230.672 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 90%
Metabolism Hepatic oxidation and sulfate conjugation
Half life 21-45 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(AU) C(US)
Legal status

POM(UK) ℞-only(US)
Routes Oral, intravenous

Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

It is used as a vasodilator in the treatment of acute hypertension, and also to decrease the secretion of insulin in disease states such as insulinoma (a tumor producing insulin).

Pills  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.


v • d • e
Antihypertensives (C02) and diuretics (C03)
Antiadrenergic agents (including alpha) Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine,Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine
Vasodilators Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine
Other antihypertensives Bosentan, Ketanserin
Low ceiling diuretics Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine, Cicletanine
High ceiling diuretics Bumetanide, Furosemide, Torasemide
Potassium-sparing diuretics Amiloride, Eplerenone, Spironolactone, Triamterene
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