Diethylcarbamazine

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Chemical structure of Diethylcarbamazine
Diethylcarbamazine
Systematic (IUPAC) name
4-methyl-N,N-bis (4-methylpiperazin-2-yl)- piperazine-1-carboxamide
Identifiers
CAS number 90-89-1
ATC code P02CB02
PubChem 3052
DrugBank APRD00918
Chemical data
Formula C10H21N3O 
Mol. mass 199.293 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Diethylcarbamazine (DEC) (C10H21N3O) is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements. DEC is indicated for treatment of individual patients with certain filarial diseases. These diseases include: lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia, and loiasis. In cases of onchocerciasis, another common filarial parasite, the drug is not used. This is because the itching associated with the dead subcutaneous parasites causes intense and unbearable itching. DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the treatment of dog heart worm Dirofilaria immitis.

DEC is an inhibitor of Aracadonic acid metabolism in filarial mf. This makes the mf more susceptible to immune attack.

  • Hetrazan
  • Carbilazine
  • Caricide
  • Cypip
  • Ethodryl
  • Notézine
  • Spatonin
  • Filaribits
  • Banocide Forte


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