Diflunisal

From Wikipedia, the free encyclopedia

(Redirected from Dolobid)
Jump to: navigation, search
Diflunisal
Systematic (IUPAC) name
5-(2,4-difluorophenyl)-2-hydroxy-benzoic acid
Identifiers
CAS number 22494-42-4
ATC code N02BA11
PubChem 3059
DrugBank APRD00922
Chemical data
Formula C13H8F2O3 
Mol. mass 250.198 g/mol
Pharmacokinetic data
Bioavailability 80-90%
Protein binding >99%
Metabolism Hepatic
Half life 8 to 12 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(AU) C(US)
Legal status

POM(UK) ℞-only(US)
Routes Oral

Diflunisal is a generic NSAID (non-steroidal anti-inflammatory drug). It is often used under the brand name Dolobid marketed by Merck & Co. Diflunisal acts by inhibiting the production of prostaglandin, a hormone that creates inflammation and stimulates the neuro receptors for pain. Though diflunisal has an onset of 1 hour, and maximum analgesia at 2 to 3 hours, the diflunisal plasma levels will not be steady until repeated doesages are achieved. To increase the rate at which the diflunisal plasma levels become steady, a loading dose is usually used. It is primarily used to treat symptoms of arthritis.

Deaths that have occurred from diflunisal usually involved mixed drugs and or extremely high dosages. The oral LD50 is 500 mg/kg. Symptoms of overdose include, coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams. Mixed with other medicines, a death at 7.5 grams has also occurred. Diflunisal usually comes in 250 or 500 mg, thus it is relatively hard to overdose by accident.

This medication has no side effects like those of recreational drugs.

Indicated for:
  • Pain, mild-moderate
  • Osteoarthritis
  • Rheumatoid arthritis
  • Injury to tendons
  • Inflammation

Do not cut/crush/chew. Monitor blood pressure. Use lowest effective dose for shortest duration.
Side effects:

Cardiovascular:

  • Irregular heart beat (!)
  • This medication may increase risk of serious and potentially fatal cardiovascular thrombotic events, MI, and stroke (!)
  • Risk may increase with duration of use (!)
  • Increased risk for Cardiovascular disease history (!)
  • Contraindicated for Heart Bypass peri-op pain (!)

Ear, nose, and throat:

  • Ringing in the ears (!)

Eye:

  • Yellowing of eyes (!)

Gastrointestinal:

  • Increased risk of serious GI adverse events including bleeding, ulceration, and stomach or intestine perforation which can be fatal: may occur at any time during use and without warning. Elderly at greater risk for serious GI events (!)
  • Abdominal pain and cramps
  • Constipation
  • Gas & Flatulence
  • Diarrhea
  • Nausea & Vomiting
  • Dyspepsia

Central Nervous System:

  • Drowsiness
  • Dizziness
  • Headache
  • Insomnia
  • Fatigue
  • Somnolence

Psychiatric:

  • Nervousness

Skin:

  • Swelling of the feet, ankles, lower legs, and hands (!)
  • Yellowing of skin (!)
  • Rash
  • Ecchymosis

Contraindications:

  • Hypersensitivity to aspirin/NSAID-induced asthma or urticaria
  • Aspirin triad
  • Pregnancy 3rd trimester
  • CABG surgery (peri-op pain)

Cautions:

  • Cardiovascular disease
  • Cardiac risk factors
  • Hypertension
  • Congestive Heart Failure
  • Elderly or debilitated
  • Impaired liver function
  • Impaired kidney function
  • Dehydration
  • Fluid retention
  • GI bleed history/PUD
  • Asthma
  • Coagulopathy
  • Smoker
  • Corticosteriod use
  • Anticoagulant use
  • Alcohol use
  • Diuretic use
  • ACE Inhibitor use
  • Prolonged use

Precautions:

  • If symptoms labeled, (!), appear, stop usage immediately and contact your doctor.
  • Overdose is possible and deaths have occurred.
  • Do not take while on other pain medications.
  • Do not take while pregnant or breast feeding.



v • d • e
Non-steroidal anti-inflammatory drugs (primarily M01A and M02A, also N02BA)
Salicylates Aspirin (Acetylsalicylic Acid), Diflunisal, Ethenzamide, Salicin
Arylalkanoic acids Diclofenac, Etodolac, Indometacin, Nabumetone, Sulindac
2-Arylpropionic acids (profens) Carprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Ketorolac, Loxoprofen, Naproxen, Oxaprozin, Suprofen, Tiaprofenic acid
N-Arylanthranilic acids (fenamic acids) Mefenamic acid
Pyrazolidine derivatives Phenylbutazone
Oxicams Meloxicam, Piroxicam
Coxibs Celecoxib, Etoricoxib, Parecoxib, Rofecoxib, Valdecoxib, Lumiracoxib
Sulphonanilides Nimesulide
Topically used products Diclofenac, Flurbiprofen, Ibuprofen, Indometacin, Ketoprofen, Naproxen, Piroxicam, Suprofen
Others Fluproquazone
Retrieved from "http://en.wikipedia.org/wiki/Diflunisal"
Advanced Search
Included Web Search Engines


Safe Search

close

Top Matching Results

Occasionally Search.com will highlight specialized results that are based on the context of your query. Examples of specialized results include specific links to news, images, or video.

Top Matching Results may highlight information from other Search.com pages, content from the CNET Network of sites, or third party content. The listings are based purely on relevance. Search.com does not receive payment for listings in this section but our partners that provide this data may get paid for listing these products.

Sponsored Links

This section contains paid listings which have been purchased by companies that want to have their sites appear for specific search terms and related content. These listings are administered, sorted and maintained by a third party and are not endorsed by Search.com.

Search Results

Search.com sends your search query to several search engines at one time and integrates the results into one list which has been sorted by relevance using Search.com's proprietary algorithm. You can customize the list of search engines included in your metasearch from the preferences.

The search engines that are used in your metasearch may allow companies to pay to have their Web sites included within the results. To view the Paid Inclusion policy for a specific search engine, please visit their Web site. Search.com does not accept payment or share revenue with any search engine partner for listings in this section.