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Fetal Dilantin Syndrome
From Wikipedia, the free encyclopedia
Dilantin is the brand name of the drug phenytoin sodium in the United States, commonly used in the treatment of epilepsy. About one third of children whose mothers are taking this drug during pregnancy develop minor face and limb birth defects, a smaller population will have growth problems and developmental delay, or mental retardation. Heart defects and cleft lip may also be featured. The entire group of defects caused by the drug's teratogenicity is called Fetal Dilantin Syndrome. It may also be called Fetal Hydantoin Syndrome, Dilantin Embryopathy, or Phenytoin Embryopathy.
- Abnormalities of the skull and facial features
- Growth deficiencies
- Underdeveloped nails of fingers and toes
- Mild developmental delays
- Occasionally, cleft lip and/or palate, microcephaly, and brain malformations with more significant developmental delays may present.
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