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The Domus Sanctæ Marthæ (Latin for Saint Martha's House) is a building adjacent to Saint Peter's Basilica in the Vatican City built during the reign of Pope John Paul II. It functions as a guest house for those having business with the Holy See, but it is best known as the hotel residence of the College of Cardinals taking part in the papal conclaves to elect new Popes. Its amenities include furnished bedrooms, lavatories and studies for each prelate. Dining facilities and personal services are also offered.

Prior to the Apostolic Constitution Universi Dominici Gregis — promulgated on February 22, 1996 that changed the rules governing papal conclaves — participants were forced to sleep in the Apostolic Palace on rented cots, usually borrowed from seminaries in Rome. After participants were literally sealed under lock and key in the Apostolic Palace, the electors would live in makeshift rooms built throughout the palace, including within hallways and offices. The rooms, assigned to each Cardinal by lot, would often be constructed by nothing more than a sheet hanging on a rope. Sturdier walls would not be available because of the cost and because they would damage the Palace walls. In addition to the rented cots, each room would be equipped with a Crucifix and kneeler, a desk and one or two chairs. The Cardinals would have to share common bathrooms, often with ten Cardinals assigned to each.

Pope John Paul II, after himself participating in two Conclaves, decided to make the process more comfortable and less strenuous on the elderly Cardinals and commissioned the construction of Domus Sanctæ Marthæ.

As with previous practise, the Cardinals would be assigned their rooms by lot. Cardinals' rankings would have no effect on which room they would receive. Cardinal Ratzinger, in the 2005 Conclave, was assigned to a simple room even though he was the Cardinal Dean and one of the longest-serving in the College; after he had been elected Pope, he was invited to transfer to the fancier Patriarchal Suite.

During a Conclave, all radios, television sets and telephones would be disconnected, as per regulations which call for the Cardinals to be secluded from the outside world to prevent any undue influence on their voting.