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Enflurane
From Wikipedia, the free encyclopedia
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Enflurane
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| Systematic (IUPAC) name | |
| 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane | |
| Identifiers | |
| CAS number | |
| ATC code | N01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C3H2ClF5O |
| Mol. mass | 184.492 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 97% |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether that was commonly used for inhalational anesthesia during the 1970s and 1980s. Developed by Ross Terrell in 1963, it was first used clinically in 1966.
Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.
Clinically, enflurane produces a dose-related depression of myocardial contractility with an associated decrease in myocardial oxygen consumption. Between 2% and 5% of the inhaled dose is oxidised in the liver, producing fluoride ions and difluoromethoxy-difluoroacetic acid. This is significantly higher than the metabolism of its structural isomer isoflurane.
| Molecular weight | 184.5 g/mol | ||
| Boiling point (at 1 atm): | 56.5 °C | ||
| MAC : | 1.68 | ||
| Vapor pressure: | 172 mmHg | (at 20°C) | |
| Blood:Gas Partition Coefficient: | 1.9 | ||
| Oil:Gas Partition Coefficient: | 98 |
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| Barbiturates | Hexobarbital, Methohexital, Narcobarbital, Thiopental |
| Ethers | Diethyl ether,Desflurane, Enflurane, Isoflurane, Methoxyflurane, Methoxypropane, Sevoflurane, Vinyl ether |
| Haloalkanes | Chloroform, Halothane, Trichloroethylene |
| Opioids | Alfentanil, Anileridine, Fentanyl, Phenoperidine, Remifentanil, Sufentanil |
| Others | Alfaxalone, Droperidol, Esketamine, Etomidate, Hydroxybutyric acid, Ketamine, Minaxolone, Nitrous oxide, Propanidid, Propofol, Xenon |
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