Thyroid epithelial cell
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Thyroid epithelial cells (also called follicular cells or principal cells) are cells in the thyroid gland which produce and secrete thyroxine (T4) and triiodothyronine (T3).
They are simple cuboidal epithelium[1] and are arranged in spherical follicles surrounding colloid.
They have thyrotropin receptors on their surface, which respond to thyroid-stimulating hormone.
Embryologic origin is from endoderm (in contrast to parafollicular cells, below).
Calcitonin-producing parafollicular cells (C cells) can be found scattered along the basement membrane of the thyroid epithelium. Embryologic origin is from neural crest cells.
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| Hypothalamic/pituitary axes | Adrenal axis: Adrenal gland
Thyroid axis: Thyroid gland (Parafollicular cell, Thyroid epithelial cell) - Parathyroid gland (Oxyphil cell, Chief cell) Gonadal axis: Testes - Ovaries - Corpus luteum |
| Other | Pineal gland • Islets of pancreas |