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Esophagus
Head and neck.
Digestive organs. (Esophagus is #1)
Latin	œsophagus
Gray's	subject #245 1144
Artery	esophageal arteries
Vein	esophageal veins
Nerve	celiac ganglia, vagus[1]
Precursor	Foregut
MeSH	Esophagus
Dorlands/Elsevier	e_16/12343479

The esophagus (also spelled oesophagus/œsophagus, Greek οἰσοφάγος), or gullet is an organ in vertebrates which consists of a muscular tube through which food passes from the pharynx to the stomach. In humans, the esophagus is continuous with the laryngeal part of the pharynx at the level of the C6 vertebra.

Contents 1 Functioning 2 Histology 3 Gastroesophageal junction 4 Etymology 5 Esophageal diseases and conditions 6 Additional images 7 References 8 External links

Food is passed through the esophagus by using the process of peristalsis. Specifically, it connects the pharynx, which is the body cavity that is common to the digestive factory and respiratory system with the stomach, where the second stage of digestion is initiated.

The esophagus is lined with mucous membrane, and is more deeply lined with muscle that acts with peristaltic action to move swallowed food down to the stomach.

The swallowing sound that we hear is the esophagus at work.

The layers of the esophagus are as follows:^[2]

• mucosa
  • nonkeratinized stratified squamous epithelium: is rapidly turned over, and serves a protective effect due to the high volume transit of food, saliva and mucous.
  • lamina propria: sparse.
  • muscularis mucosae: smooth muscle

submucosa: Contains the mucous secreting glands (esophageal glands), and connective structures termed papillae.

• muscularis externa (or "muscularis propria"): composition varies in different parts of the esophagus, to correspond with the conscious control over swallowing in the upper portions and the autonomic control in the lower portions:
  • upper third, or superior part: striated muscle
  • middle third, smooth muscle and striated muscle,
  • inferior third: predominantly smooth muscle.
• adventitia

The junction between the esophagus and the stomach (the gastroesophageal junction or GE junction) is not actually considered a valve, although it is sometimes called the cardiac sphincter, cardia or cardias, but is actually more of a stricture.

It derives from Greek; hiοiσω -oeso, future tense of the verb φερω-to bring and from the verb έφαγον,-phagus, past tense of τρώγω-to eat. The word "esophagus" is the result of the "o" being dropped from the oe (or œ) in "oesophagus". This vowel does not exist in English but in most other Indoeuropean languages as œ, ö, or ø. In mostly the rest of the non-US world, and according standard international latin and greek medical nomemclature, the spelling oesophagus (similarly œsophagus, ösofagus, or øsofagus) is used.

Many people experience a burning sensation in their chest occasionally, caused by stomach acids refluxing into the esophagus, normally called heartburn. Extended exposure to heartburn may erode the lining of the esophagus, leading potentially to Barrett's esophagus which is associated an increased risk of adenocarcinoma most commonly found in the distal one-third of the oesophagus.

Some people also experience a sensation known as globus esophagus, where it feels as if a ball is lodged in the lower part of the esophagus.

The following are additional diseases and conditions that affect the oesophagus:

• Achalasia
• Chagas disease
• Caustic injury to the esophagus
• Esophageal atresia and Tracheoesophageal fistula
• Esophageal cancer
• Esophageal web
• Esophagitis
• GERD
• Hiatus hernia
• Mallory-Weiss syndrome
• Neurogenic dysphagia
• Schatzki's ring
• Zenker's Diverticulum
• Boerhaave syndrome

H&E stain of biopsy of normal esophagus showing the stratified squamous cell epithelium	Layers of the esophagus.	Mid esophageal mass	Stomach
Accessory digestive system.	Organs of the digestive tract.	Section of the neck at about the level of the sixth cervical vertebra.	Transverse section of thorax, showing relations of pulmonary artery.
Sagittal section of nose mouth, pharynx, and larynx.	The position and relation of the esophagus in the cervical region and in the posterior mediastinum. Seen from behind. |	Section of the human esophagus. Moderately magnified.	Microscopic shot of a cross section of human gastro-esophageal junction wall.

1. ^ Physiology at MCG 6/6ch2/s6ch2_30
2. ^ Histology at BU 10801loa

• Virtual Slidebox at Univ. Iowa Slide 449

v • d • e Anatomy of torso, digestive system: Gastrointestinal tract
Upper GI: to stomach	Mouth • Pharynx (nasopharynx, oropharynx, hypopharynx) • Esophagus • Crop
Upper GI: stomach	rugae - gastric pits - cardia/gland - fundus/gland - pylorus/gland - pyloric antrum - pyloric canal - greater curvature - lesser curvature - angular incisure
Lower GI: intestines	Small intestine: Duodenum (Suspensory muscle, Major duodenal papilla, Minor duodenal papilla) • Duodenojejunal flexure • Jejunum • Ileum • continuous (intestinal villus, crypts of Lieberkühn, circular folds) Junction: Vermiform appendix • Ileocecal valve Large intestine: Cecum • Colon (ascending colon, hepatic flexure, transverse colon, splenic flexure, descending colon, sigmoid colon) • continuous (taenia coli, haustra, epiploic appendix)
Lower GI: termination	Rectum: Houston valve • rectal ampulla • pectinate line Anal canal: anal valves • anal sinuses • anal columns • Hilton's white line Anus: Sphincter ani internus muscle • Sphincter ani externus muscle
Lower GI: lymph	GALT: Peyer's patches (M cells)