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Exsanguination (also known colloquially as bleeding out) is the fatal process of total hypovolemia (blood loss). It is most commonly known as "bleeding to death." The word itself originated from Latin: 'ex' (out of) and 'sanguis' (blood). Therefore the word literally means 'out of blood'.

Exsanguination is used primarily in the meat industry, as a method of slaughter. In some places, before the incision is made, a device called a captive bolt is used. The device is placed against the skull of the animal, and penetrates to cause tissue destruction in the brain incapacitating the animal so that the procedure may take place. This procedure may not be used everywhere, and its use is forbidden for halal and kosher slaughter.

While the animal is incapacitated, a knife is fully inserted through the skin just behind the point of the jaw and below the neck bones. From this position the knife is drawn forward severing the jugular vein, carotid artery, and trachea. Properly performed, blood should flow freely with death occurring within a few minutes.

Beyond the initial cost of purchasing a captive bolt, continued usage of the method is very inexpensive. The animal is incapacitated for the duration of the procedure, so it is one of the safest methods for the slaughterer.

Slaughter by exsanguination is mandated by Judaic kashrut and Islamic halal dietary laws. However, the captive bolt is forbidden in both religions.

Exsanguination is a relatively uncommon and dramatic cause of death in humans. It might be more precise to say that exsanguination is a mode of death rather than a cause, since the fact of exsanguination will have some underlying cause. It is essentially bleeding to death. Exsanguination is a suicide method caused by cutting of arteries, notably: carotid, radial, ulnar, and femoral arteries.

Trauma (injury) can cause exsanguination if bleeding is not stymied. It is the most common cause of deaths on the battlefield (though the most common cause of death from battle is infection). Non-battlefield causes can include partial or complete amputation from use of circular saws (e.g., hand-held circular saw, radial arm saw, table saw).

Patients can also develop catastrophic internal hemorrhages, such as from a bleeding peptic ulcer or splenic hemorrhage, which can cause exsanguination even without any external bleeding. It is a relatively common cause of unexpected, sudden death in patients who seemed previously well.^{[citation needed]}

Alcoholics can also suffer from exsanguination. Thin-walled dilated veins just below the lower esophageal mucosa called esophageal varices may ulcerate or be torn ("Mallory-Weiss syndrome") during the violent retching of the alcoholic leading to massive bleeding and sometimes exsanguination.

Exsanguination is also the name of a song by the punk band, AFI, from the album, Black Sails in the Sunset.

It is used as a lyric in the song "Blood Drenched Execution" by the death metal band, Cannibal Corpse, from the album, Gallery of Suicide.

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