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FYVE domain
From Wikipedia, the free encyclopedia
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FYVE zinc finger
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| Identifiers | ||
| Symbol | FYVE | |
| Pfam | ||
| InterPro | ||
| SCOP | ||
| OPM family | 62 | |
| OPM protein | 1vfy | |
| Available PDB structures:
1dvpA:156-219 1vfyA:168-230 1jocB:1347-1411 1hyjA:1347-1411 1hyiA:1347-1411 1wfkA:2-59 1x4uA:349-411 |
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FYVE zinc finger domain is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1.
The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. FYVE domains bind Phosphatidylinositol 3-phosphate.
The FYVE finger is structural similarity to RING domain and PHD finger.
ANKFY1; EEA1; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; FYCO1; HGS; MTMR3; MTMR4; PIP5K3; PLEKHF1; PLEKHF2; RUFY1; RUFY2; WDF3; WDFY1; WDFY2; WDFY3; ZFYVE1; ZFYVE16; ZFYVE19; ZFYVE20; ZFYVE21; ZFYVE26; ZFYVE27; ZFYVE28; ZFYVE9;
- [1]. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. Stenmark H, Aasland R, Toh BH, D'Arrigo A; J Biol Chem 1996;271:24048-24054. PubMed
- [2]. FYVE fingers bind PtdIns(3)P. Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R; Nature 1998;394:432-433. PubMed
- [3]. FYVE-finger proteins - effectors of an inositol lipid. Stenmark H, Aasland R; J Cell Sci 1999;112:4175-4183. PubMed
- FYVE domain in Pfam
- UMich Orientation of Proteins in Membranes families/superfamily-62 - Orientations of FYVE/PHD zinc finger domains in membranes (OPM)
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| BZIP - DED - Kringle - PH - SH2 - SH3 - zinc finger - FYVE - PX - ENTH - BAR - PDZ - CARD - SUN - TRIO - C1 - LIM - C2 |