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Follistatin
From Wikipedia, the free encyclopedia
| Follistatin | |
|---|---|
 The Structure Of The Follistatin:Activin Complex |
|
| Other names: | FS, Activin-binding protein |
| Genetic data | |
| Gene code: | HUGO code:FST |
| Protein Structure/Function | |
| Structure: | Follistatin:Activin Complex structure |
| Protein type: | Growth factor |
| Functions: | Regulates members of the TGF beta superfamily ligands |
| Domains: | 3 FOLN domains, 3 KAZAL domains |
| Other | |
| Taxa expressing: | Homo Sapiens; homologs: many metazoan phyla |
| Cell types: | many, placenta, blood, ovary, liver, testis |
| Subcellular localization: | extracellular |
| Molecular interactions: | Activin, inhibin, BMP5 |
| Medical/Biotechnological data | |
| Diseases: | polycystic ovary syndrome (PCOS) |
Follistatin is a single chain gonadal protein that inhibits Follicle-stimulating hormone release. It binds to and antagonizes Activin, which enhances FSH secretion. There are three known isoforms created by alternative splicing.
| Identifiers | |
| Symbol | FST |
| HUGO | 3971 |
| Entrez | 10468 |
| OMIM | 136470 |
| RefSeq | NM_013409 |
| UniProt | P19883 |
| Other data | |
| Locus | Chr. 5 q11.2 |
TGF beta superfamily of ligands:
Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3
Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1
Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
Acyl carrier protein - Adaptor protein - F-box protein - GTP-binding protein - Light-harvesting complex - Membrane transport protein
Calcium-binding protein - Calmodulin-binding proteins - Ceruloplasmin - Cholesterylester transfer protein - Iron-binding proteins - Retinol binding protein - Transferrin receptor - Transcobalamins
Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II)
Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin
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