Fomivirsen

From Wikipedia, the free encyclopedia

Fomivirsen
Systematic (IUPAC) name
 ?
Identifiers
CAS number 160369-77-7
ATC code S01AD08
PubChem  ?
Chemical data
Formula C204H263N63O114P20S20 
Mol. mass 6682.4 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B2
Legal status
Routes Intravitreal injection

Fomivirsen (brand name Vitravene) is an antiviral drug. It is used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS.

It is an oligonucleotide that blocks transcription of viral mRNA by bindng to a coding segment of a key CMV gene. It was the first antisense antiviral approved by the FDA.

  • Diagram
  • MedlinePlus DrugInfo uspdi-203675
  • DDB 31313
  • (2001) "Fomivirsen.". Drugs Today (Barc) 37 (4): 245-255. PMID 12768225. 
  • Geary R, Henry S, Grillone L (2002). "Fomivirsen: clinical pharmacology and potential drug interactions.". Clin Pharmacokinet 41 (4): 255-60. PMID 11978144. 
  • (2002) "Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS.". Am J Ophthalmol 133 (4): 475-83. PMID 11931781. 
  • Roehr B (1998). "Fomivirsen approved for CMV retinitis.". J Int Assoc Physicians AIDS Care 4 (10): 14-6. PMID 11365956. 
v • d • e
Antivirals (primarily J05A, also S01AD and D06BB)
Anti-herpesvirus Aciclovir, Cidofovir, Docosanol, Famciclovir, Fomivirsen, Foscarnet, Ganciclovir, Idoxuridine, Penciclovir, Trifluridine, Tromantadine, Valaciclovir, Valganciclovir, Vidarabine
Anti-influenza agents Amantadine, Arbidol, Oseltamivir, Peramivir, Rimantadine, Zanamivir
Antiretrovirals: NRTIs Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Zalcitabine, Zidovudine
Antiretrovirals: NtRTIs Tenofovir
Antiretrovirals: NNRTIs Efavirenz, Delavirdine, Nevirapine, Loviride
Antiretrovirals: PIs Amprenavir, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir
Antiretrovirals: Fusion inhibitors Enfuvirtide
Other antiviral agents Adefovir, Fomivirsen, Imiquimod, Inosine, Interferon, Podophyllotoxin, Ribavirin, Viramidine
Pills  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org../../../f/o/m/Fomivirsen.html"
Advanced Search
Included Web Search Engines


Safe Search

close

Top Matching Results

Occasionally Search.com will highlight specialized results that are based on the context of your query. Examples of specialized results include specific links to news, images, or video.

Top Matching Results may highlight information from other Search.com pages, content from the CNET Network of sites, or third party content. The listings are based purely on relevance. Search.com does not receive payment for listings in this section but our partners that provide this data may get paid for listing these products.

Sponsored Links

This section contains paid listings which have been purchased by companies that want to have their sites appear for specific search terms and related content. These listings are administered, sorted and maintained by a third party and are not endorsed by Search.com.

Search Results

Search.com sends your search query to several search engines at one time and integrates the results into one list which has been sorted by relevance using Search.com's proprietary algorithm. You can customize the list of search engines included in your metasearch from the preferences.

The search engines that are used in your metasearch may allow companies to pay to have their Web sites included within the results. To view the Paid Inclusion policy for a specific search engine, please visit their Web site. Search.com does not accept payment or share revenue with any search engine partner for listings in this section.