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Fusidic acid
From Wikipedia, the free encyclopedia
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Fusidic acid
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| Systematic (IUPAC) name | |
| 2-(16-acetyloxy-3,11-dihydroxy-4,8,10,14- tetramethyl- 2,3,4, 5,6,7, 9,11,12, 13,15,16- dodecahydro- 1H-cyclopenta [a]phenanthren-17-ylidene) -6-methyl- hept-5-enoic acid | |
| Identifiers | |
| CAS number | |
| ATC code | J01 |
| PubChem | |
| Chemical data | |
| Formula | C31H48O6 |
| Mol. mass | 516.709 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Fusidic acid is an antibiotic used particularly for eye and skin infections.
It works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome, although it works only on gram-positive bacteria such as Staphylococcus aureus, Streptococcus and Corynebacterium minutissimum. Therefore it is bacteriostatic.
It was first isolated in 1962 from the fungus Fusidium coccineum, and later from Mucor ramannianus and Isaria kogana.
It is delivered as an ointment, a cream, eye drops or in tablet form.
- Fusidin (of Leo in Canada)
- Fucidin (of Leo in UK)
- Fucithalmic (of Leo in UK and Denmark)
- Fucicort
- Fucibet
- RxMed Monograph
- Synthesis of photoreactive fusidic acid analogues for binding studies with elongation factor G
Adosterol - Cholecalciferol/Ergocalciferols - Cholesterol - Dihydrotachysterol - Fusidic acid - Lanosterol - Phytosterols - Solanine