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The GDB Human Genome Database is a community curated collection of human genomic data. What set GDB apart from other biological databases, was its use of world-class leaders in human genetics to act as curators for the data. In order to ensure a high degree of quality, records within GDB were subjected to a process of peer-review, not unlike a traditional publication. Due to the International collaboration which made up the human genome project, GDB received funding from numerous sources in both Europe and Asia.

In 1989 the Howard Hughes Medical Institute provided funding to establish a central repository for human genetic mapping data. This project ultimately resulted in the creation of the GDB Human Genome DataBase in 1990. It was a key database in the human genome project.

Established under the leadership of Dr.'s Peter Person and Dick Lucier, GDB received significant financial support from the US Department of Energy and the National Institutes of Health. Located at the Johns Hopkins University School of Medicine, GDB became a source of high quality mapping data which were made available both on-line as well as through numerous printed publications.

In 1998, the change of focus in the human genome project redirected funds which were previously available for GDB. However that same year, Dr. A. Jamie Cuticchia obtained funding from Canadian public and private sources to continue the operations of GDB. While the data curation continued to be performed at Johns Hopkins, GDB central operations were moved to The Hospital for Sick Children in Toronto, Ontario, Canada.

In 2003 RTI International became the new host for GDB where it continues to be maintained as a public resource for high quality genetic and genomic information.

• The GDB Human Genome DataBase