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Doctor Who character
Dr Grace Holloway
Grace
Affiliated with	Eighth Doctor
Race	Human
Home planet	Earth
Home era	1999
First appearance	Doctor Who (1996)
Last appearance	Doctor Who (1996)
Portrayed by	Daphne Ashbrook

Dr. Grace Holloway is a fictional character played by Daphne Ashbrook in the 1996 television movie Doctor Who, a continuation of the long-running British science fiction television series Doctor Who. A cardiologist from 1999 San Francisco, she assisted the Eighth Doctor against the renegade Time Lord known as the Master.

When the Seventh Doctor lands on December 30, 1999 in San Francisco, he is gunned down by a gang on the streets of Chinatown. Unaware of his alien physiology, Grace accidentally kills him when she attempts to operate. He subsequently regenerates into his eighth incarnation, and involves Grace in his fight to prevent the Master from opening the Eye of Harmony and destroying the Earth at the stroke of midnight on New Year's Day, 2000. At the end, the Doctor offers to take Grace along with him in the TARDIS, but Grace declines, preferring to stay behind and apply the lessons she has learned from him.

Grace is described by the Doctor as "tired of life but afraid of dying." She is a warm and compassionate person who was disillusioned early in life when she realized that she could not hold back death. As a result, she puts on a cold, aloof front in an effort to protect herself from her feelings and to mask her own insecurity. She realizes this over the course of her adventure with the Doctor and learns to feel hope again, placing it in the form of the Doctor, an alien who can literally come back to life, as well as regaining confidence in herself as a medical practitioner and as a person.

Grace's appearance in the television movie caused controversy because the Doctor kissed her, breaking a longstanding taboo against having any romantic involvement with his companions. Some fans also question whether she can be considered a proper companion since she only appears in this one story. However, it is clear that her role within the television movie is the companion's, and she appears listed on most lists of companions, including the one on the BBC website.

Grace's life after her encounter with the Doctor has not been explored on-screen beyond the television movie, although the Doctor did have to deal with the after effects of those events in the spin-off Eighth Doctor Adventures novel Unnatural History, by Kate Orman and Jonathan Blum.

Grace appeared in the Doctor Who comic strip story The Fallen, published in Doctor Who Magazine #273-#276, where she had conducted experiments to merge human and Time Lord DNA, the latter obtained from tissue left behind by the Master. However, the Master had not been in his Time Lord body, but that of a shape-shifting creature known as a morphant. The resulting hybrid began to consume people, but was stopped with the Eighth Doctor's help. Grace promised the Doctor she would destroy all the remaining morphant DNA samples, and the two parted ways once more. She subsequently appeared as a dream image in The Glorious Dead (DWM #287-#296) and made a one-panel cameo in the last regular Eighth Doctor comic strip adventure, The Flood (DWM #353). The canonicity of the comic strips in relation to the television series, like other Doctor Who spin-off media, is unclear.

Daphne Ashbrook performed in the Big Finish Productions audio play The Next Life opposite Paul McGann as the Eighth Doctor, but playing a different character named Perfection.