GroES

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Heat shock 10kDa protein 1 (chaperonin 10)
Identifiers
Symbol(s) HSPE1; CPN10; GROES; HSP10
External IDs OMIM: 600141 MGI: 104680 Homologene: 20500
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3336 15528
Ensembl ENSG00000115541 ENSMUSG00000073676
Uniprot P61604 Q4KL76
Refseq NM_002157 (mRNA)
NP_002148 (protein)		 NM_008303 (mRNA)
NP_032329 (protein)
Location Chr 2: 198.07 - 198.08 Mb Chr 1: 55.03 - 55.04 Mb
Pubmed search [1] [2]

Heat shock 10kDa protein 1 (chaperonin 10), also known as HSPE1 or GroES, is a chaperonin which usually works in conjunction with GroEL.[1] In eukaryotes, it is very similar to Heat Shock Protein 10 or Hsp10.


  1. ^ Entrez Gene: HSPE1 heat shock 10kDa protein 1 (chaperonin 10).

  • Czarnecka AM, Campanella C, Zummo G, Cappello F (2007). "Heat shock protein 10 and signal transduction: a "capsula eburnea" of carcinogenesis?". Cell Stress Chaperones 11 (4): 287-94. PMID 17278877. 
  • Legname G, Fossati G, Gromo G, et al. (1995). "Expression in Escherichia coli, purification and functional activity of recombinant human chaperonin 10.". FEBS Lett. 361 (2-3): 211-4. PMID 7698325. 
  • Cavanagh AC, Morton H (1994). "The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10.". Eur. J. Biochem. 222 (2): 551-60. PMID 7912672. 
  • Monzini N, Legname G, Marcucci F, et al. (1994). "Identification and cloning of human chaperonin 10 homologue.". Biochim. Biophys. Acta 1218 (3): 478-80. PMID 7914093. 
  • Chen JJ, McNealy DJ, Dalal S, Androphy EJ (1994). "Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10.". Biochim. Biophys. Acta 1219 (1): 189-90. PMID 7916212. 
  • Samali A, Cai J, Zhivotovsky B, et al. (1999). "Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells.". EMBO J. 18 (8): 2040-8. doi:10.1093/emboj/18.8.2040. PMID 10205158. 
  • Summers KM, Fletcher BH, Macaranas DD, et al. (2000). "Mapping and characterization of the eukaryotic early pregnancy factor/chaperonin 10 gene family.". Somat. Cell Mol. Genet. 24 (6): 315-26. PMID 10763410. 
  • Richardson A, Schwager F, Landry SJ, Georgopoulos C (2001). "The importance of a mobile loop in regulating chaperonin/ co-chaperonin interaction: humans versus Escherichia coli.". J. Biol. Chem. 276 (7): 4981-7. doi:10.1074/jbc.M008628200. PMID 11050098. 
  • Fletcher BH, Cassady AI, Summers KM, Cavanagh AC (2001). "The murine chaperonin 10 gene family contains an intronless, putative gene for early pregnancy factor, Cpn10-rs1.". Mamm. Genome 12 (2): 133-40. PMID 11210183. 
  • Parissi V, Calmels C, De Soultrait VR, et al. (2001). "Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60.". J. Virol. 75 (23): 11344-53. doi:10.1128/JVI.75.23.11344-11353.2001. PMID 11689615. 
  • Hansen JJ, Dürr A, Cournu-Rebeix I, et al. (2002). "Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.". Am. J. Hum. Genet. 70 (5): 1328-32. PMID 11898127. 
  • Guidry JJ, Wittung-Stafshede P (2002). "Low stability for monomeric human chaperonin protein 10: interprotein interactions contribute majority of oligomer stability.". Arch. Biochem. Biophys. 405 (2): 280-2. PMID 12220543. 
  • Lee KH, Kim HS, Jeong HS, Lee YS (2002). "Chaperonin GroESL mediates the protein folding of human liver mitochondrial aldehyde dehydrogenase in Escherichia coli.". Biochem. Biophys. Res. Commun. 298 (2): 216-24. PMID 12387818. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hansen JJ, Bross P, Westergaard M, et al. (2003). "Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.". Hum. Genet. 112 (1): 71-7. doi:10.1007/s00439-002-0837-9. PMID 12483302. 
  • Mansell JP, Yarram SJ, Brown NL, Sandy JR (2004). "Type I collagen synthesis by human osteoblasts in response to placental lactogen and chaperonin 10, a homolog of early-pregnancy factor.". In Vitro Cell. Dev. Biol. Anim. 38 (9): 518-22. PMID 12703979. 
  • Cappello F, Bellafiore M, David S, et al. (2003). "Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix.". Cancer Lett. 196 (1): 35-41. PMID 12860287. 
  • Shan YX, Liu TJ, Su HF, et al. (2004). "Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells.". J. Mol. Cell. Cardiol. 35 (9): 1135-43. PMID 12967636. 
  • Shan YX, Yang TL, Mestril R, Wang PH (2003). "Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy.". J. Biol. Chem. 278 (46): 45492-8. doi:10.1074/jbc.M304498200. PMID 12970367. 
  • Guidry JJ, Shewmaker F, Maskos K, et al. (2004). "Probing the interface in a human co-chaperonin heptamer: residues disrupting oligomeric unfolded state identified.". BMC Biochem. 4: 14. doi:10.1186/1471-2091-4-14. PMID 14525625. 

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v • d • e
Chaperones
Heat shock proteins/Chaperonins Hsp10/GroES - Hsp27 - Hsp47 - Hsp60/GroEL - Hsp70 (Hsc70) - Hsp90
Other Alpha crystallin - Clusterin
Retrieved from "http://en.wikipedia.org/wiki/GroES"
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