Neonatal hemochromatosis

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Neonatal Hemochromatosis is a rare and severe liver disease. It's characteristics are similar to hereditary hemochromatosis, where iron deposition causes damage to the liver and other organs and tissues.

The causes of neonatal hemochromatosis are still unknown, however recent research has led to the hypothesis that it is an alloimmune disease (see autoimmunity). Evidence supporting this hypothesis includes the high recurrence rate within sibships (>80%).

Effective treatment of the disease has been confined to liver transplants. An antioxidant chelation cocktail has also been reported as having some success though its effectiveness cannot be confirmed.

Based on the alloimmune cause hypothesis, a new treatment involving high-dose immunoglobulin to pregnant mothers who have had a previous pregnancy with a confirmed neonatal hemochromatosis outcome, has provided very encouraging results.[1]

  1. ^ Whitington PF, Hibbard JU (2004 Nov 6-12). "High-dose immunoglobulin during pregnancy for recurrent neonatal haemochromatosis". The Lancet 364 (9446): 1690-8. PMID 15530630. 

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