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Henry C. Dalton (born May 7, 1847) was superintendent of the St. Louis City Hospital from 1886 to 1892, and later a professor of abdominal and clinical surgery at Marion Sims College of Medicine (now part of the St. Louis University School of Medicine) . He is noted for performing the first suturing of the pericardium on record. The operation occurred on September 6, 1891 at the City Hospital, on a twenty-two-year-old man who had been stabbed in the chest. Upon arrival of the patient, Dalton cleaned the wound and applied a dressing of antiseptic gauze. After several hours, the patient's condition worsened: the left side of his chest became dull to percussion; his temperature and pulse rate rose; his breathing became shallow; and he complained of considerable pain. He was taken to the surgical amphitheatre, where Dalton made an incision over the fourth rib and removed about six inches of it. After tying the severed intercostal artery to control bleeding and removing the blood from the pleural cavity, Dalton observed a transverse wound of the pericardium about two inches in length. With a sharply curved needle and catgut, he closed the wound by continuous suture, overcoming great difficulty caused by the heart pulsations. The pleural cavity was then irrigated and the chest incision closed without drainage. The patient made "an uninterrupted, rapid recovery." The published report of the operation appeared in the state medical association's journal and another local periodical in 1894, and in the Annals of Surgery the following year.

• Henry C. Dalton. Report of a case of stab wound of the pericardium, terminating in recovery after resection of a rib and suture of the pericardium. Annals of Surgery 1895, 21:147-152
• Harris B. Shumacker, Jr. Evolution of Cardiac Surgery. Bloomington, Indiana: University Press, 1992
• Stephen L. Johnson, The History of Cardiac Surgery, Baltimore: Johns Hopkins Press, 1970
• William Hyde, Howard L. Conard, eds. Encyclopedia of the History of St. Louis, a Compendium of History and Biography for Ready Reference. New York: Southern History Co., 1899.