Sources
Help build the largest human-edited directory on the web.
Submit a site - Become an editor
Wikipedia. Licensed under the GNU Free Documentation License.
Are you an expert in this subject? Join the discussion and share your knowledge at Wikipedia.org.
Hexobarbital
From Wikipedia, the free encyclopedia
 |
|
|
Hexobarbital
|
|
| Systematic (IUPAC) name | |
| 5-(1-cyclohexenyl)- 1,5-dimethyl- hexahydropyrimidine- 2,4,6-trione | |
| Identifiers | |
| CAS number | |
| ATC code | N01 N05CA16 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C12H16N2O3 |
| Mol. mass | 236.267 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 25% |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery and has a relatively fast onset of effects and short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days. Hexobarbital is still used in some scientific research.
- Takenoshita R, Toki S (2004). "[New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases]". Yakugaku Zasshi 124 (12): 857-71. PMID 15577260.
- Wahlström G (1998). "A study of the duration of acute tolerance induced with hexobarbital in male rats.". Pharmacol Biochem Behav 59 (4): 945-8. PMID 9586853.
- Korkmaz S, Ljungblad E, Wahlström G (1995). "Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat.". Brain Res 676 (2): 371-7. PMID 7614008.
- Dall V, Orntoft U, Schmidt A, Nordholm L (1993). "Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital.". Pharmacol Biochem Behav 46 (1): 73-6. PMID 8255925.
Allobarbital, Amobarbital, Aprobarbital, Alphenal, Barbexaclone, Barbital, Butabarbital, Butalbital, Butobarbital, Butallylonal, Cyclobarbital, Cyclopal, Ethallobarbital, Hexethal, Heptabarbital, Hexobarbital, Mephobarbital, Metharbital, Methohexital, Methylphenobarbital, Narcobarbital, Pentobarbital, Probarbital, Proxibarbital, Propallylonal, Reposal, Secobarbital, Talbutal, Thialbarbital, Thiamylal, Thiobarbital, Thiobutabarbital Thiopental, Vinbarbital, Vinylbital
|
|
|
|---|---|
| Barbiturates | Hexobarbital, Methohexital, Narcobarbital, Thiopental |
| Ethers | Diethyl ether,Desflurane, Enflurane, Isoflurane, Methoxyflurane, Methoxypropane, Sevoflurane, Vinyl ether |
| Haloalkanes | Chloroform, Halothane, Trichloroethylene |
| Opioids | Alfentanil, Anileridine, Fentanyl, Phenoperidine, Remifentanil, Sufentanil |
| Others | Alfaxalone, Droperidol, Esketamine, Etomidate, Hydroxybutyric acid, Ketamine, Minaxolone, Nitrous oxide, Propanidid, Propofol, Xenon |
 |
This medical article is a stub. You can help Wikipedia by expanding it. |