Hippocalcin

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hippocalcin
Identifiers
Symbol HPCA
HUGO 5144
Entrez 3208
OMIM 142622
RefSeq NM_002143
UniProt P84074
Other data
Locus Chr. 1 p35-p34.2

Hippocalcin is a calcium-binding protein that belongs to neuronal calcium sensors (NCS) family of proteins. It expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.

It takes part in the following prosesses:

  • Activation of PLD and PLD2 expression
  • Involved in long term depression in hippocampal neuron


It interacts with following proteins:

  • Neuronal apoptosis inhibitory protein (NAIP)
  • Mixed lineage kinase 2 (MLK2)
  • The b2 adaptin of the AP2 complex
  • Calcium-dependent activator protein for secretion (CAPS)
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