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Histoplasmosis
Classification & external resources

Histoplasma capsulatum. Methenamine silver stain showing histopathologic changes in histoplasmosis.
ICD-10	B39
ICD-9	115
DiseasesDB	5925
MedlinePlus	001082
eMedicine	med/1021  ped/1017

Histoplasmosis, also known as Darling's disease, is a disease caused by the fungus Histoplasma capsulatum. Its symptoms vary greatly, but the disease primarily affects the lungs. Occasionally, other organs are affected—this form of the disease is called disseminated histoplasmosis, and it can be fatal if untreated. H. capsulatum is found throughout the world and is endemic in certain areas of the United States, particularly in states bordering the Ohio River valley and the lower Mississippi River. The fungus has been found in poultry house litter, caves, areas harboring bats, and in bird roosts (particularly those of starlings). The fungus is thermal dimorphic. In the environment it grows as a brownish mycelium, whereas at body temperature it morphs into a yeast. The inoculum is represented principally by microconidia that once inhaled into the alveolar spaces germinate and then transform into budding yeast cells.

Contents 1 Incidence 2 Transmission 3 Symptoms 4 Treatment 5 Prevention 6 External links

Positive histoplasmin skin tests occur in as many as 80% of the people living in areas where H. capsulatum is common, such as the eastern and central United States. Infants, young children, and older persons, in particular those with chronic lung disease, are at increased risk for severe disease. Disseminated disease is more frequently seen in people with weakened immune systems such as those suffering from cancer or AIDS.

H. capsulatum grows in soil and material contaminated with bat or bird droppings. Spores (called microconidia) become airborne when contaminated soil is disturbed. Breathing the spores causes infection. When the spores reach the lungs they turn into yeast, which causes the disease. The disease is not transmitted from an infected person to someone else. Plants fertilized with bat droppings may contain spores and when burned the smoke becomes infectious.

If symptoms occur, they will start within 3 to 17 days after exposure; the average is 10 days. Most infected persons have no apparent ill effects. The acute respiratory disease is characterized by respiratory symptoms, a general ill feeling, fever, chest pains, and a dry or nonproductive cough. Distinct patterns may be seen on a chest x-ray. Chronic lung disease resembles tuberculosis and can worsen over months or years. The disseminated form is fatal unless treated. While histoplasmosis is the most common cause of fibrosing mediastinitis, this remains a relatively rare disease.its also causing hepatospleenomegaly even in acute pulmonary cases.Lesions have tendency to calcify as they heal.

Antifungal medications are used to treat severe cases of acute histoplasmosis and all cases of chronic and disseminated disease. Mild disease usually resolves without treatment. Past infection results in partial protection against ill effects if reinfected.

It is not practical to test or decontaminate most sites that may be contaminated with H. capsulatum, but the following precautions can be taken to reduce a person's risk of exposure:

• Avoid areas that may harbor the fungus, e.g., accumulations of bird or bat droppings.
• Before starting a job or activity having a risk for exposure to H. capsulatum, consult the NIOSH/NCID Document Histoplasmosis: Protecting Workers at Risk. This document contains information on work practices and personal protective equipment that will reduce the risk of infection. It takes a while to diagnose this condition.

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Note: The original version of this article is adapted from the U.S. CDC public domain document at http://www.cdc.gov/ncidod/dbmd/diseaseinfo/histoplasmosis_g.htm

• NIOSH - Histoplasmosis - Protecting Workers at Risk
• Fibrosing Mediastinitis