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Mothers against decapentaplegic homolog 1
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| SMAD, Mothers against decapentaplegic homolog 1 | |
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 Crystalline Structure of SMAD1 |
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| Other names: | SMAD 1, Mothers against DPP homolog 1, Mad-related protein, Transforming growth factor-beta signaling protein 1, BSP-1, hSMAD1, JV4-1 |
| Genetic data | |
| Gene code: | HUGO code:SMAD1 |
| Protein Structure/Function | |
| Protein type: | protein coding |
| Functions: | signal transduction, transcription |
| Domains: | MH1, MH2 |
| Other | |
| Taxa expressing: | homo sapiens; homolog: many metazoan phyla |
| Cell types: | ubiquitous |
| Subcellular localization: | Primary:nucleus, Alternative:cytoplasm |
| Covalent modifications: | phosphorylation |
SMAD1 or Mothers against decapentaplegic homolog 1 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which modulate the TGFβ superfamily of ligands. Like many other TGFβ family modulators SMAD1 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD1 protein. SMAD1 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
| Identifiers | |
| Symbol | SMAD1 |
| Alt. Symbols | MADH1 |
| Entrez | 4086 |
| HUGO | 6767 |
| OMIM | 601595 |
| RefSeq | NM_005900 |
| UniProt | Q15797 |
| Other data | |
| Locus | Chr. 4 q31.21 |
The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein SMA. The name is a combination of the two. During Drosophila research, it was found that a mutation in the gene, MAD, in the mother, repressed the gene, decapentaplegic, in the embryo. The phrase "Mothers against" was added since mothers often form organizations opposing various issues eg. Mothers Against Drunk Driving or (MADD).
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| TGF beta superfamily of ligands | TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors | TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan |
| Transducers/SMAD | R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors | Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors | BAMBI - Cripto |
| Other | SARA |
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