Inositol triphosphate receptor

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inositol 1,4,5-triphosphate receptor, type 1
Identifiers
Symbol ITPR1
Entrez 3708
HUGO 6180
OMIM 147265
RefSeq NM_002222
UniProt Q14643
Other data
Locus Chr. 3 p26.1
inositol 1,4,5-triphosphate receptor, type 2
Identifiers
Symbol ITPR2
Entrez 3709
HUGO 6181
OMIM 600144
RefSeq NM_002223
UniProt Q14571
Other data
Locus Chr. 12 p11.23
inositol 1,4,5-triphosphate receptor, type 3
Identifiers
Symbol ITPR3
Entrez 3710
HUGO 6182
OMIM 147267
RefSeq NM_002224
UniProt Q14573
Other data
Locus Chr. 6 p21.31

Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca2+ channel activated by inositol triphosphate (IP3).

Contents

It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3R's are found in the cell integrated into the endoplasmic reticulum.

The IP3R complex is formed of four 313 kDa subunits. In amphibians, fish and mammals there are 3 paralogs and these can form homo- or hetero-oligomers. IP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life. It is additionally the means for further IP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. Combinations of these can be introduced into a given transcript in order to modulate its pharmacological activity.

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v • d • e
Cell signaling: lipid signaling
Phospholipase - PIP2 - DAG - IP3 - IP3 receptor
v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel Voltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, β-subunits (β1, β2, β4), γ-subunits (γ2) • Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel
Na+: Sodium channel Navα (1.1, 1.2, 1.4, 1.5, 1.7, 1.9) • Navβ (1, 3, 4) • Epithelial sodium channel
K+: Potassium channel Voltage-gated (Kv(1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 4.2, 4.3, 7.1, 7.2, 7.3, 7.4, 10.1, 11.1/hERG), Shaker gene, KCNE1 • Calcium-activated (BK channel, SK channel, SK3) • Inward-rectifier Kir (1.1, 2.1, 2.2, 2.3, 3.1, 3.2, 3.4, 4.1, 4.2, 6.1, 6.2)) • Tandem pore domain
Cl-: Chloride channel Cystic fibrosis transmembrane conductance regulator
Porin Aquaporin (1, 2, 3, 4) • Voltage-dependent anion channel
Cations: TRP TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2)• TRPV (1, 2, 3, 4, 5, 6)
Other/general Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel • Stretch-activated ion channel
Retrieved from "http://en.wikipedia.org/wiki/Inositol_triphosphate_receptor"
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