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Isaac, Itzhak or Yitzhak (Hebrew: יִצְחָק, Standard Yiẓḥaq Tiberian Yiṣḥāq ; Arabic: إسحٰق, ʾIsḥāq ; "he will laugh") is one of the patriarchs, whose story is told in the Biblical book of Genesis. (See also Binding of Isaac for the narrative of Abraham's near-sacrifice of Isaac).

Isaac is a given name, popular in both Christian and Jewish societies, generally in reference to the above. Izzy is also a short-form of the name Isaac. Famous people named "Isaac" include:

• Isaac Albéniz, composer
• Isaac of Antioch, 5th century Christian writer
• Isaac Asimov, writer
• Major-General Sir Isaac Brock
• Isaac Brock (musician), lead singer of the band Modest Mouse
• Isaac Hanson, musician, guitarist of the band Hanson
• Isaac Hayes, singer
• Isaac Isaacs, politician
• Isaac Mizrahi, fashion designer
  • Isaac (TV show), his eponymous TV show on the Style Network
• Isaac Newton, physicist
• Isaac of Nineveh, 7th century Christian writer
• Itzhak Perlman, violinist
• Yitzhak Rabin, prime minister of Israel
• Yitzhak Shamir, prime minister of Israel
• Isaac Singer, inventor
• Isaac Slade, lead singer of the band The Fray]
• Isaac Smith (multiple people)
• Isaac Stern, violinist
• Isaac Watts, hymn-writer

• Arthur Isaac, English cricketer
• Bobby Isaac, American racing driver
• Glynn Isaac, South African archaeologist
• Ugonis, Henricus, Heinrich or Arrigo Issac or Ysaac, Franco-Flemish composer
• John Isaac, English cricketer
• Luis Isaac, Puerto Rican baseball player
• Oscar Isaac, American actor
• Rhys L. Isaac, American historian
• Robert M. Isaac, mayor of Colorado Springs

• Chris Isaak, American musician

• Isaac, a main character in Nintendo's Golden Sun series.
• Isaac, the northeasternmost country in the Fire Emblem universe continent Jugdral, where the video games Fire Emblem: Seisen no Keifu and Fire Emblem: Thracia 776 take place.
• ISAAC (cipher), a cryptographically secure pseudorandom number generator.
• Sacrifice of Isaac (Caravaggio), two paintings by master artist Caravaggio depicting the Biblical scene of the binding of Isaac

• Isaacs

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