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Karen O'Neil Ganci (born 1974) is an American portrait artist who gained national attention as a contestant on the American version of Big Brother 5, a reality TV show broadcast by CBS in 2004.

She has been married to husband Larry Ganci since 1996.

She splits her time between her NJ studio and Florida. In Florida she has been commissioned by the Ted Williams Museum in Hernando, Florida to create artwork each year for their Hitter's Hall of Fame induction plaques. She also performs comedy all up and down the east coast, including at Jacksonville, Florida's The Comedy Zone [1] .

In 1993 at just 19 years old, Karen started her own art studio. She had extensive training from her hands-on training with illustrator Lori Anzalone [2] . She focused on portraits of people, usually placed on collectible items. Her subjects were generally famous people, especially those in professional sports. Most of her work is done in the New Jersey/New York area, as well as Florida. She has also attempted a career in stand up comedy and music. Her career as a portrait artist has achieved the most commercial success. Her work is the focus of KONGart in Lodi, New Jersey.

(2005)Karen was one of fourteen Big Brother 5 contestants. Karen survived to be one of the five remaining contestants, along with Drew Daniel, Michael Ellis, Diane Henry, and Jennifer Dedmon. Only Drew and Diane were eligible to vote, and both voted to evict Karen. Karen left the house on Day 70.

(2007) Karen was named the official 'Hush Girl' spokesmodel. She appears regularly on the Home Shopping network to present the Hush Fragrance line of home fragrances.

• KarenOneilGanci.com - Official Website of Karen O'Neil Ganci detailing Karen's latest career news
• KONGart.com - Official Art Website of Karen O'Neil Ganci's
  • Autobiography of Karen O'Neil Ganci
  • Karen O'Neil Ganci Singer/Songwriter Artist/Animator Actor/Comedian - This page focusses more on what Karen's done beyond her original art work.
  • Appearances with celebrities - Pictures of Karen, with some of the famous people she did portraits of, such as Ted Williams, Joe DiMaggio, Nolan Ryan, Yogi Berra, Muhammed Ali, Alfonso Soriano, Lawrence Taylor, and Peyton Manning.
• Karen O'Neil Ganci at the Internet Movie Database
• Profile of Karen O'Neil Ganci by CBS for Big Brother 5 (contestant)
• Profile of Karen O'Neil Ganci by CBS for Big Brother 6 (guest commentator)
• Profile of Karen O'Neil Ganci at JokersUpdates.com
• "Karen O'Neil-Ganci Is The 10th Houseguest Officially Evicted" RealityReel.com. September 13, 2004.
• "Spring Hill portrait artist stars in Big Brother 5" St. Petersburg Times. July 8, 2004
• "Lodi artist steps up to the palette, and the plate" (reprint) By Shannon D. Harrington, The Sunday Record. March 4, 2005.
• "Week Eight: Artist erased from 'Big Brother'" By John Powell, CANOE JAM! Television. December 14, 2004.