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L-gulonolactone oxidase
From Wikipedia, the free encyclopedia
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gulonolactone (L-) oxidase pseudogene
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| Identifiers | |
| Symbol | GULOP |
| HUGO | 4695 |
| Entrez | 2989 |
| OMIM | 240400 |
| RefSeq | NG_001136 |
| Other data | |
| EC number | 1.1.3.8 |
| Locus | Chr. 8 p21.1 |
L-gulonolactone oxidase (EC 1.1.3.8) is an enzyme that catalyzes the reaction of D-glucuronolactone (also known as L-gulono-1,4-lactone) with oxygen to L-xylo-hex-3-ulonolactone and hydrogen peroxide. It uses FAD as a cofactor.
The CAS number for this enzyme is 9028-78-8
The non-functional GULOP was mapped to human chromosome 8p21 that corresponds to an evolutionarily conserved segment on either porcine chromosome 4 (SSC4) or 14 (SSC14).[1] GULO produces ascorbic acid, which is often called "vitamin C".
Animals that have lost the ability to synthesize vitamin C are, notably: simians (primates), guinea pigs, the red-vented bulbul, fruit-eating bats and a species of trout.[2]
Gulonolactone oxidase deficiency is called "hypoascorbemia"[3] and is described by OMIM (Online Mendelian Inheritance in Man)[4] as "a public inborn error of metabolism", as it affects all humans. There exists a wide discrepancy between the amounts of ascorbic acid other primates consume and what is recommended as "reference intakes" for humans.[5]
- ^ GULOP - iHOP
- ^ Vitamin C – Risk Assessment. UK Food Standards Agency. Retrieved on 2007-02-19.
- ^ HYPOASCORBEMIA - NCBI
- ^ OMIM - Online Mendelian Inheritance in Man - NCBI
- ^ Micronutrient intakes of wild primates: are humans different?. Retrieved on 2007-03-11.
Carbohydrate dehydrogenases - L-gulonolactone oxidase - Glucose oxidase - Isocitrate dehydrogenase - Lactate dehydrogenase - Malate dehydrogenase - Xanthine oxidase
hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD)