Myosin light-chain kinase

From Wikipedia, the free encyclopedia

(Redirected from Myosin light chain kinase)
Jump to: navigation, search
myosin, light polypeptide kinase
Identifiers
Symbol MYLK
Entrez 4638
HUGO 7590
OMIM 600922
RefSeq NM_053025
UniProt Q15746
Other data
EC number 2.7.11.18
Locus Chr. 3 qcen-q21
myosin light chain kinase 2, skeletal muscle
Identifiers
Symbol MYLK2
Entrez 85366
HUGO 16243
OMIM 606566
RefSeq NM_033118
UniProt Q9H1R3
Other data
Locus Chr. 20 q13.31

Myosin-light-chain kinase (MLCK) is a serine/threonine-specific protein kinase which phosphorylates myosin.

This protein is important in the mechanism of contraction in smooth muscle. Once there is an influx of calcium into the smooth muscle, either from the sarcoplasmic reticulum or more importantly from the extracellular space, contraction of smooth muscle fibres may begin. First the calcium will bind to calmodulin. This binding will activate MLCK, which will go on to phosphorylate the myosin light chain at serine residue 19. This will enable the myosin crossbridge to bind to the actin filament and allow contraction to begin (through the crossbridge cycle). Since smooth muscle does not contain a troponin complex like striated muscle does, this mechanism is the main pathway for regulating smooth muscle contraction.

 This transferase article is a stub. You can help Wikipedia by expanding it.
v • d • e
Kinases: Serine/threonine-specific protein kinases (primarily EC 2.7.11)
2.7.11 Pyruvate dehydrogenase kinase - Protein kinase A - Protein kinase G - Protein kinase C (Protein kinase Mζ) - Rhodopsin - Beta adrenergic receptor - G-protein coupled receptor kinases - Ca2+/calmodulin-dependent - Myosin light-chain) - Phosphorylase - Cyclin-dependent - Mitogen-activated (Extracellular signal-regulated, C-Jun N-terminal (MAPK8, MAPK9), P38 mitogen-activated protein) - MAP3K - GSK-3 - AMP-activated
2.7.12 MAP2K
2.7.1.37, or unknown Anti-Mullerian hormone receptor - Ataxia telangiectasia mutated - Aurora (A, B) - Mammalian target of rapamycin - Bone morphogenetic protein receptors (1, 2) - CDKL5 - c-Raf - EIF-2 - Ribosomal s6 - Protein kinase B - PDK1
Retrieved from "http://en.wikipedia.org/wiki/Myosin_light-chain_kinase"
Advanced Search
Included Web Search Engines


Safe Search

close

Top Matching Results

Occasionally Search.com will highlight specialized results that are based on the context of your query. Examples of specialized results include specific links to news, images, or video.

Top Matching Results may highlight information from other Search.com pages, content from the CNET Network of sites, or third party content. The listings are based purely on relevance. Search.com does not receive payment for listings in this section but our partners that provide this data may get paid for listing these products.

Sponsored Links

This section contains paid listings which have been purchased by companies that want to have their sites appear for specific search terms and related content. These listings are administered, sorted and maintained by a third party and are not endorsed by Search.com.

Search Results

Search.com sends your search query to several search engines at one time and integrates the results into one list which has been sorted by relevance using Search.com's proprietary algorithm. You can customize the list of search engines included in your metasearch from the preferences.

The search engines that are used in your metasearch may allow companies to pay to have their Web sites included within the results. To view the Paid Inclusion policy for a specific search engine, please visit their Web site. Search.com does not accept payment or share revenue with any search engine partner for listings in this section.