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Lipofuscin
From Wikipedia, the free encyclopedia
Lipofuscin is the name given to brown pigment granules composed of lipid-containing residues of lysosomal digestion. It is considered one of the aging or "wear and tear" pigments; found in the liver, kidney, heart muscle, adrenals, nerve cells, and ganglion cells. "Liver spots" commonly associated with aging are superficial dermal lipofuscin deposits.
Some studies show lesser deposits of lipofuscin in calorie restricted diet.
Abnormal accumulation of lipofuscin is associated with a group of diseases of neurodegenerative disorder type called lipofuscinoses, e.g., neuronal ceroid lipofuscinosis, also known as Batten disease, as well as some other names.
- Terman A, Brunk U (2004). "Lipofuscin.". Int J Biochem Cell Biol 36 (8): 1400-4. PMID 15147719.
- Histology at neuro.wustl.edu
- Histology at BU 20301loa
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