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This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.

Contents 1 EC 6.1: Forming Carbon-Oxygen Bonds 1.1 EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds 2 EC 6.2: Forming Carbon-Sulfur Bonds 2.1 EC 6.2.1: Acid-Thiol Ligases 3 EC 6.3: Forming Carbon-Nitrogen Bonds 3.1 EC 6.3.1: Acid-Ammonia (or Amine) Ligases (Amide Synthases) 3.2 EC 6.3.2: Acid—Amino-Acid Ligases (Peptide Synthases) 3.3 EC 6.3.3: Cyclo-Ligases 3.4 EC 6.3.4: Other Carbon-Nitrogen Ligases 3.5 EC 6.3.5: Carbon-Nitrogen Ligases with Glutamine as Amido-N-Donor 4 EC 6.4: Forming Carbon-Carbon Bonds 5 EC 6.5: Forming Phosphoric Ester Bonds 6 EC 6.6: Forming Nitrogen—Metal Bonds 6.1 EC 6.6.1: Forming Coordination Complexes

• EC 6.1.1.1: tyrosine—tRNA ligase
• EC 6.1.1.2: tryptophan—tRNA ligase
• EC 6.1.1.3: threonine—tRNA ligase
• EC 6.1.1.4: leucine—tRNA ligase
• EC 6.1.1.5: isoleucine—tRNA ligase
• EC 6.1.1.6: lysine—tRNA ligase
• EC 6.1.1.7: alanine—tRNA ligase
• EC 6.1.1.8: deleted
• EC 6.1.1.9: valine—tRNA ligase
• EC 6.1.1.10: methionine—tRNA ligase
• EC 6.1.1.11: serine—tRNA ligase
• EC 6.1.1.12: aspartate—tRNA ligase
• EC 6.1.1.13: D-alanine-poly(phosphoribitol) ligase
• EC 6.1.1.14: glycine—tRNA ligase
• EC 6.1.1.15: proline—tRNA ligase
• EC 6.1.1.16: cysteine—tRNA ligase
• EC 6.1.1.17: glutamate—tRNA ligase
• EC 6.1.1.18: glutamine—tRNA ligase
• EC 6.1.1.19: arginine—tRNA ligase
• EC 6.1.1.20: phenylalanine—tRNA ligase
• EC 6.1.1.21: histidine—tRNA ligase
• EC 6.1.1.22: asparagine—tRNA ligase
• EC 6.1.1.23: aspartate—tRNAAsn ligase
• EC 6.1.1.24: glutamate—tRNAGln ligase
• EC 6.1.1.25: lysine—tRNAPyl ligase

• EC 6.2.1.1: acetate—CoA ligase
• EC 6.2.1.2: butyrate—CoA ligase
• EC 6.2.1.3: long-chain-fatty-acid—CoA ligase
• EC 6.2.1.4: succinate—CoA ligase (GDP-forming)
• EC 6.2.1.5: succinate—CoA ligase (ADP-forming)
• EC 6.2.1.6: glutarate—CoA ligase
• EC 6.2.1.7: cholate—CoA ligase
• EC 6.2.1.8: oxalate—CoA ligase
• EC 6.2.1.9: malate—CoA ligase
• EC 6.2.1.10: acid—CoA ligase (GDP-forming)
• EC 6.2.1.11: biotin—CoA ligase
• EC 6.2.1.12: 4-coumarate—CoA ligase
• EC 6.2.1.13: acetate—CoA ligase (ADP-forming)
• EC 6.2.1.14: 6-carboxyhexanoate—CoA ligase
• EC 6.2.1.15: arachidonate—CoA ligase
• EC 6.2.1.16: acetoacetate—CoA ligase
• EC 6.2.1.17: propionate—CoA ligase
• EC 6.2.1.18: citrate—CoA ligase
• EC 6.2.1.19: long-chain-fatty-acid—luciferin-component ligase
• EC 6.2.1.20: long-chain-fatty-acid—(acyl-carrier-protein) ligase
• EC 6.2.1.21: covered by EC 6.2.1.30
• EC 6.2.1.22: (citrate (pro-3S)-lyase) ligase
• EC 6.2.1.23: dicarboxylate—CoA ligase
• EC 6.2.1.24: phytanate—CoA ligase
• EC 6.2.1.25: benzoate—CoA ligase
• EC 6.2.1.26: o-succinylbenzoate—CoA ligase
• EC 6.2.1.27: 4-hydroxybenzoate—CoA ligase
• EC 6.2.1.28: 3a,7a-dihydroxy-5b-cholestanate—CoA ligase
• EC 6.2.1.29: deleted now EC 6.2.1.7
• EC 6.2.1.30: phenylacetate—CoA ligase
• EC 6.2.1.31: 2-furoate—CoA ligase
• EC 6.2.1.32: anthranilate—CoA ligase
• EC 6.2.1.33: 4-chlorobenzoate—CoA ligase
• EC 6.2.1.34: trans-feruloyl-CoA synthase

• EC 6.3.1.1: aspartate—ammonia ligase
• EC 6.3.1.2: glutamate—ammonia ligase
• EC 6.3.1.3: now EC 6.3.4.13
• EC 6.3.1.4: aspartate—ammonia ligase (ADP-forming)
• EC 6.3.1.5: NAD+ synthase
• EC 6.3.1.6: glutamate—ethylamine ligase
• EC 6.3.1.7: 4-methyleneglutamate—ammonia ligase
• EC 6.3.1.8: glutathionylspermidine synthase
• EC 6.3.1.9: trypanothione synthase
• EC 6.3.1.10: adenosylcobinamide-phosphate synthase
• EC 6.3.1.11: glutamate—putrescine ligase

• EC 6.3.2.1: pantoate—b-alanine ligase
• EC 6.3.2.2: glutamate—cysteine ligase
• EC 6.3.2.3: glutathione synthase
• EC 6.3.2.4: D-alanine—D-alanine ligase
• EC 6.3.2.5: phosphopantothenate—cysteine ligase
• EC 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase
• EC 6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
• EC 6.3.2.8: UDP-N-acetylmuramate—L-alanine ligase
• EC 6.3.2.9: UDP-N-acetylmuramoylalanine—D-glutamate ligase
• EC 6.3.2.10: UDP-N-acetylmuramoylalanyl-tripeptide—D-alanyl-D-alanine ligase
• EC 6.3.2.11: carnosine synthase
• EC 6.3.2.12: dihydrofolate synthase
• EC 6.3.2.13: UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diamino-pimelate ligase
• EC 6.3.2.14: 2,3-dihydroxybenzoate—serine ligase
• EC 6.3.2.15: deleted, due to EC 6.3.2.10
• EC 6.3.2.16: D-alanine—alanyl-poly(glycerolphosphate) ligase
• EC 6.3.2.17: tetrahydrofolate synthase
• EC 6.3.2.18: g-glutamylhistamine synthase
• EC 6.3.2.19: ubiquitin—protein ligase
• EC 6.3.2.20: indoleacetate—lysine synthetase
• EC 6.3.2.21: ubiquitin—calmodulin ligase
• EC 6.3.2.22: diphthine—ammonia ligase
• EC 6.3.2.23: homoglutathione synthase
• EC 6.3.2.24: tyrosine—arginine ligase
• EC 6.3.2.25: tubulin—tyrosine ligase
• EC 6.3.2.26: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
• EC 6.3.2.27: aerobactin synthase

• EC 6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase
• EC 6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase
• EC 6.3.3.3: dethiobiotin synthase
• EC 6.3.3.4: (carboxyethyl)arginine b-lactam-synthase

• EC 6.3.4.1: GMP synthase
• EC 6.3.4.2: CTP synthase
• EC 6.3.4.3: formate—tetrahydrofolate ligase
• EC 6.3.4.4: adenylosuccinate synthase
• EC 6.3.4.5: argininosuccinate synthase
• EC 6.3.4.6: urea carboxylase
• EC 6.3.4.7: ribose-5-phosphate—ammonia ligase
• EC 6.3.4.8: imidazoleacetate—phosphoribosyldiphosphate ligase
• EC 6.3.4.9: biotin—(methylmalonyl-CoA-carboxytransferase) ligase
• EC 6.3.4.10: biotin—(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase
• EC 6.3.4.11: biotin—(methylcrotonoyl-CoA-carboxylase) ligase
• EC 6.3.4.12: glutamate—methylamine ligase
• EC 6.3.4.13: phosphoribosylamine—glycine ligase
• EC 6.3.4.14: biotin carboxylase
• EC 6.3.4.15: biotin—(acetyl-CoA-carboxylase) ligase
• EC 6.3.4.16: carbamoyl-phosphate synthase (ammonia)
• EC 6.3.4.17: formate—dihydrofolate ligase

• EC 6.3.5.1: NAD+ synthase (glutamine-hydrolysing)
• EC 6.3.5.2: GMP synthase (glutamine-hydrolysing)
• EC 6.3.5.3: phosphoribosylformylglycinamidine synthase
• EC 6.3.5.4: asparagine synthase (glutamine-hydrolysing)
• EC 6.3.5.5: carbamoyl-phosphate synthase (glutamine-hydrolysing)
• EC 6.3.5.6: asparaginyl-tRNA synthase (glutamine-hydrolysing)
• EC 6.3.5.7: glutaminyl-tRNA synthase (glutamine-hydrolysing)
• EC 6.3.5.8: aminodeoxychorismate synthase
• EC 6.3.5.9: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
• EC 6.3.5.10: adenosylcobyric acid synthase (glutamine-hydrolysing)

• EC 6.4.1.1: pyruvate carboxylase
• EC 6.4.1.2: acetyl-CoA carboxylase
• EC 6.4.1.3: propionyl-CoA carboxylase
• EC 6.4.1.4: methylcrotonoyl-CoA carboxylase
• EC 6.4.1.5: geranoyl-CoA carboxylase
• EC 6.4.1.6: acetone carboxylase

• EC 6.5.1.1: DNA ligase (ATP)
• EC 6.5.1.2: DNA ligase (NAD+)
• EC 6.5.1.3: RNA ligase (ATP)
• EC 6.5.1.4: RNA-3'-phosphate cyclase

• EC 6.6.1.1: magnesium chelatase
• EC 6.6.1.2: cobaltochelatase