While researching anti-gravity, brilliant grad student Quinn Mallory accidentally opens an inter-dimensional portal which sends him and three companions on a cosmic roller-coaster ride to parallel Earths. 

When Wade is infected with a deadly virus on an Earth wracked by an epidemic, Rembrandt and Arturo race to find a cure and free Quinn from a Gestapo-like health agency. 

The salvation of a world facing destruction by an asteroid rests in the hands of Arturo and an overzealous young scientist. Meanwhile, Quinn and Wade Begin to face their feelings for each other. 

In a world where England won the Revolutionary War, the Sliders are embroiled in an assassination plot involving the heir to the throne and an evil Sheriff of San Francisco. 

The Sliders find themselves in a present-day San Francisco where the "Summer of Love" never ended – and Wade and Rembrandt are mistaken for extraterrestrial prophets. 

While Quinn struggles with fame in a world where intellect is prized, Arturo tries for a reconciliation with a long-lost love. 

Arturo finds himself in a potentially deadly mayoral race in a world where men are treated as "the weaker sex" and women hold the positions of power and influence. 

It looks like the King is back when Rembrandt is mistaken for a long-deceased rock legend, but an old enemy would like to see the Crying Man disappear again – permanently. 

Wade finds that she has money to burn when she wins the lottery in a seemingly utopian world, but she soon discovers that her silver cloud has a very dark lining. 

On an alternate Earth immersed in occult practices, Quinn becomes the target of a shaman who demands his brain as payment for services rendered. 

Quinn, Rembrandt and Arturo are tagged as runaway breeders on a world where, due to a biological weapon outbreak, men are scarce and nations are in cutthroat competition to snag fertile men to repopulate. 

A slide gone wrong results in Quinn becoming lost in the astral plane, and the only person who can possibly help him is a girl with paranormal abilities. The world they've landed on is constrained by "anti-technology" laws that resulted from the atomic bombings on Japan, crimping Arturo's efforts to repair the timer. 

Quinn's fast draw with a gun embroils him in a corporate takeover on a world where California is part of the independent republic of Texas, and securities law allows gunfighting. 

Quinn rescues a woman on a dystopian world, and her boyfriend, swearing vengeance, jumps the slide. 

On a world where the United States Constitution has been outlawed, the sliders attempt to preserve the world's final copy of the document and save an activist from public execution. 

The sliders are confused with animal poachers when they land on a world where San Francisco is a preserve for dinosaurs. 

Wade, Rembrandt, and Arturo believe they have landed on Earth Prime, but Quinn has doubts. Arturo undergoes an unexpected change of character. 

The sliders land on a world dominated by psychics. The Prime Oracle (who is the most powerful person in the world due to his psychic powers) falls in love with Wade and attempts to keep her from sliding. 

Rembrandt is confused with his double on a world where alcohol prohibition was never repealed and gangs dominate society. He discovers his counterpart is a federal agent. 

Quinn impersonates his recently deceased double on a world where the young dominate society and middle-aged people are prohibited from working and have curfews. 

The group arrives on a new world in the middle of an alien invasion, and learn that the invaders are sliders that can move through the gateways at will. 

The sliders get involved with doubles of the same group of people on three different worlds, including the double of a high school girlfriend of Quinn. In one of the worlds, time is moving in the opposite direction, causing them to be in prison, then taken to their arraignment before being set free. 

The sliders land in the middle of a real live-action war game that they must finish in order to escape. 

Quinn offers to assist a scientist named Logan St. Claire fix her sliding technology in exchange for using the equipment to find his home coordinates. However, Arturo later discovers Logan does not have good intentions for the use of sliding technology. 

The sliders land in a barren wasteland with bizzare electrical activity that attracts tornadoes. 

The sliders land on a world identical to Earth Prime except that the events that occurred in 1984 on Earth Prime are occurring in 1996 on this earth. 

The group arrives on a world where terrorists discovered drugs that can invade people's dreams, and one of them chooses Wade as his next target. 

The sliders become involved in a struggle for control over a woman who can detect water on a desert world. 

A wizard wants to capture Quinn on a world where the Mallory family has special powers. 

Quinn and Arturo communicate with a fire-based lifeform. 

The sliders land on a world where men get pregnant. Rembrandt is confused with his double and is impregnated with his double's son. 

Quinn's double is wanted for murder and Quinn is arrested instead. He is sentenced to death, and the other sliders decide that finding Quinn's double is the only way to save Quinn. 

On a world where the human population has been replaced with androids, a scientist wants to transplant Quinn and Rembrandt's brains into android hosts. 

The sliders land onto a world dominated by commercialism, and get jobs working in a giant mall two days before Christmas. They later discover that the workers are basically indentured servants, and Arturo attempts to prevent one worker from abandoning her infant child. 

Arturo is brainwashed into believing he is a great literary detective named Reginald Doyle (this world's equivalent of Sherlock Holmes). 

The group lands on a world dominated by Egyptian culture, and must escape from a pyramid while being hunted by a large scarab. 

The sliders land on a world where a giant worm eats people. 

When the sliders land on an earth that is about to be destroyed by the radiation of a pulsar, a military unit forces them to help them fix their sliding technology so they can transport people to a parallel world. 

Quinn and Maggie find an alternate earth to transport 150 surivivors from the previous earth and Quinn finds the coordinates of Earth Prime. However, Rickman has a hidden agenda for the survivors. 

Quinn is infected with a bacterium that turns people into zombies. 

Maggie is infected with a parasite that takes control of her body and attempts to find a mate. 

Quinn and Wade get stuck in an underground city. 

The sliders find Rickman on a superstitious world. 

Quinn and Rembrandt are separated from Wade and Maggie after their plane crashes in the jungle. They attempt to reunite by assisting people attempting to capture deadly snakes. 

The sliders return to the world with the 150 survivors from The Exodus to find that it is inhabited by dinosaurs. 

Wade makes friends with vampire musicians who want to steal the timer. 

Rickman and the sliders are trapped on an island with a scientist who has created a race of human-animal hybrids. 

Three months after being separated from Rembrandt and Wade, Quinn and Maggie return to Earth Prime to find it has been conquered by the Kromaggs. 

The sliders land on a world dominated by a religion where people wish to travel to the other side through a vortex. After one of the leaders witnesses the sliders arrive on this earth, and after the sliders learn that people are being killed on this earth instead of transported to a parallel world, the timer is confiscated. 

Maggie saves the life of a Kromagg on a world where Kromaggs are conducting experiments on humans. 

The sliders land on a world where everyone uses virtual reality all the time. 

The sliders land on a world where Quinn's double slid the entire population except himself. 

Quinn locates his brother on a world with less technology than Earth Prime. 

Maggie and Colin are given drugs in a society where drug use is mandatory and people can be arrested for non-possession. 

The Chandler Hotel is haunted. 

Quinn and Colin attempt to slide to Kromagg Prime but end up in a slidecage designed to prevent the Kromaggs from returning to that earth. 

When Quinn is injured, the only one who can save him is a doctor who has been taught Kromagg healing techniques--but who is also wanted for providing assistance to the Kromaggs. 

On a racist world, Rembrandt is forced into slavery. 

The sliders land on a world used as a Kromagg training camp, where Kromaggs hunt humans. 

The sliders are separated on a world where in every public place, there is a television set showing a talk show called Lipschitz Live!. Quinn becomes a guest on the show to announce his location to the others. 

The sliders rescue a human woman and her half-human/half-Kromagg infant son. 

The group is separated on a world divided between computer experts and ruthless scavengers. 

Maggie's double impersonates her and slides with Quinn, Rembrandt, and Colin. 

Archibald Chandler of the Chandler Hotel turns the sliders into computer data and makes them follow his wishes. 

On a world resembling the "Old West", the sliders encounter Kolitar, the Kromagg from "Slidecage" 

Quinn is mistaken for his double's clone on a world where clones are kept as organ donors. 

The sliders land in a village with technology that drains the happiness of one person to make the rest of the villagers happy. 

A "bubble universe" envelops Quinn and Maggie. 

After finding a science fiction novel that resembles the Kromagg Prime's conflict between the humans and Kromaggs, Quinn and Colin hope that the author can help them find Kromagg Prime and meet their birthparents. 

A scientist named Dr. Oberon Geiger uses Colin, Quinn and Quinn's double as guinea pigs for an experiment that combines people and parallel worlds. 

Diana attempts to separate Quinn and his double, while the combined version experiences violent flashbacks from Quinn's life. 

The sliders land on a barren wasteland and are forced to participate in a neverending battle with the Kromaggs. 

The sliders seeks assistance from reclusive monks who later refuse to let them leave. 

Mallory is shot with a laser beam and ends up paralyzed, and looks for help from a group of spiritual healers. 

Maggie is kidnapped by a corporate conglomerate. 

A tabloid newspaper spreads a rumor that the president of the United States is having an affair with Maggie. 

The sliders land on a world where caffeine is outlawed. 

Maggie is mistaken for her astronaut double and is kidnapped by conspirators. 

On a world where gas powered vehicles are outlawed due to the pollution they generate, Mallory becomes friends with a group of motorcycle riders. 

Rembrandt receives visions from Wade. 

Diana and Mallory become trapped at a mental institution. 

The sliders arrive on a world where the local population participates in deadly arcade simulators. 

The sliders exit a vortex in the middle of the ocean, and must join the crew of a pirate ship in order to get back to California. 

The sliders must find a gem needed to repair their malfunctioning timer. 

The group lands on a world where Rembrandt is regarded as a deity. 

In their final encounter with Dr. Geiger, the scientist reveals that he can separate Mallory from his double Quinn. 

On a world with a television program based on the sliders' adventures, a psychic predicts the sliders' fate.