Lofexidine

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Lofexidine
Systematic (IUPAC) name
2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
Identifiers
CAS number	?
ATC code	N07BC04
PubChem	?
Chemical data
Formula	C₁₁H₁₂Cl₂N₂O
Mol. mass	259.131 g/mol
Pharmacokinetic data
Bioavailability	>90%
Protein binding	80–90%
Metabolism	Hepatic glucuronidation
Half life	11 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK)
Routes	Oral

Lofexidine is an alpha₂-adrenergic receptor agonist, can be used as a short acting (short half life) anti-hypertensive, but mostly used to help with relief from symptoms of heroin or opiate withdrawal in opiate dependency. Used primarily in the United Kingdom [1]. See also clonidine.

v • d • e Antihypertensives (C02) and diuretics (C03)
Antiadrenergic agents (including alpha)	Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine,Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine
Vasodilators	Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine
Other antihypertensives	Bosentan, Ketanserin
Low ceiling diuretics	Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine, Cicletanine
High ceiling diuretics	Bumetanide, Furosemide, Torasemide
Potassium-sparing diuretics	Amiloride, Eplerenone, Spironolactone, Triamterene

Retrieved from "http://en.wikipedia.org../../../l/o/f/Lofexidine.html"

Category: Antihypertensive agents

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