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Mammary gland
Cross section of the breast of a human female.
Dissection of a lactating breast. 1 - Fat 2 - Lactiferous duct/lobule 3 - Lobule 4 - Connective tissue 5 - Sinus of lactiferous duct 6 - Lactiferous duct
Latin	glandula mammaria
Gray's	subject #271 1267
Dorlands/Elsevier	g_06/12392474

Mammary glands are the organs that, in mammals, produce milk for the sustenance of the young. These exocrine glands are enlarged and modified sweat glands are the characteristic of mammals which gave the class its name.

Contents 1 Humans 1.1 Structure 1.2 Development and hormonal control 1.3 Breast cancer 2 Other mammals 3 Evolution of Mammary gland 4 Examples 5 See also 6 External links 7 References

Main article: breast

The basic components of the mammary gland are the alveoli (hollow cavities, a few millimetres large) lined with milk-secreting cuboidal cells and surrounded by myoepithelial cells. These alveoli join up to form groups known as lobules, and each lobule has a lactiferous duct that drains into openings in the nipple. The myoepithelial cells can contract, similar to muscle cells, and thereby push the milk from the alveoli through the lactiferous ducts toward the nipple, where it collects in widenings (sinuses) of the ducts. As the infant begins to suck, the hormonally mediated "let down reflex" ensues and the mother's milk is secreted into - not sucked from the gland by - the baby's mouth.

One distinguishes between a simple mammary gland, which consists of all the milk-secreting tissue leading to a single lactiferous duct, and a complex mammary gland, which consists of all the simple mammary glands serving one nipple.

Humans normally have two complex mammary glands, one in each breast, and each complex mammary gland consists of 10-20 simple glands. (The presence of more than two nipples is known as polythelia and the presence of more than two complex mammary glands as polymastia.)

The development of mammary glands is controlled by hormones. The mammary glands exist in both sexes, but they are rudimentary until puberty when in response to ovarian hormones, they begin to develop in the female. Estrogen promotes formation, while testosterone inhibits it.

At the time of birth, the baby has lactiferous ducts but no alveoli. Little branching occurs before puberty when ovarian estrogens stimulate branching differentiation of the ducts into spherical masses of cells that will become alveoli. True secretory alveoli only develop in pregnancy, where rising levels of estrogen and progesterone cause further branching and differentiation of the duct cells, together with an increase in adipose tissue and a richer blood flow.

Colostrum is secreted in late pregnancy and for the first few days after giving birth. True milk secretion (lactation) begins a few days later due to a reduction in circulating progesterone and the presence of the hormone prolactin. The suckling of the baby causes the release of the hormone oxytocin which stimulates contraction of the myoepithelial cells.

As described above, the cells of mammary glands can easily be induced to grow and multiply by hormones. If this growth runs out of control, cancer results. Almost all instances of breast cancer originate in the lobules or ducts of the mammary glands.

The number and positioning of complex and simple mammary glands varies widely in different mammals. The nipples and glands can occur anywhere along the two milk lines, two roughly-parallel lines along the ventral aspect of the body. In general most mammals develop mammary glands in pairs along these lines, with a number approximating the number of young typically birthed at a time. The number of nipples varies from 2 (in most primates, including humans, for example,) to 16 found in pigs. The Virginia Opossum has 13, one of the few mammals with an odd number^[1][2]. The following table lists the number and position of glands normally found in a range of mammals:

Species [3]	Anterior (thoracic)	Intermediate (abdominal)	Posterior (Inguinal)	Total
Goat, sheep, horse guinea pig	0	0	2	2
Cattle	0	0	4	4
Cat	2	2	0	4
Dog [4]	4	2	2-4	8-10
Mouse	6	0	4	10
Rat	6	2	4	12
Pig	6	6	4	16
elephants, primates	2	0	0	2

Male mammals typically have rudimentary mammary glands and nipples, with a few exceptions: male mice don't have nipples, and male horses lack nipples and mammary glands. The male Dyak fruit bat has lactating mammary glands. [1]

Mammary glands are true protein factories, and several companies have constructed transgenic animals, mainly goats and cows, in order to produce proteins for pharmaceutical use. Complex glycoproteins such as monoclonal antibodies or antithrombin cannot be produced by genetically engineered bacteria, and the production in live mammals is much cheaper than the use of mammalian cell cultures.

It is believed that the mammary gland is a transformed sweat gland, more closely related to Apocrine sweat glands^{[citation needed]}. There are many theories of how they evolved, but since they do not fossilize well, supporting such theories presents a major difficulty for the researcher. One theory proposes that mammary glands evolved from glands that were used to keep the eggs of early mammals moist.[2]

Cow	Pig	Sheep	Goat
Elephant	Mouse	Human

• Breast
• Nipple
• Teat
• Udder
• Milk line
• Lactation
• Milk
• Breastfeeding
• Mammary tumor for mammary gland tumors in animals
• Witch's milk

• Comparative Mammary Gland Anatomy by W. L. Hurley
• On the anatomy of the breast by Sir Astley Paston Cooper (1840). Numerous drawings, in the public domain.
• mammary+gland at eMedicine Dictionary

v • d • e Female reproductive system
Follicles/Folliculogenesis	corpus (hemorrhagicum, luteum, albicans) • Theca folliculi (externa, interna) • Follicular antrum (Follicular fluid) • Corona radiata • Zona pellucida • Membrana granulosa (Granulosa cells)
Ovaries/Oogenesis	Germinal epithelium • Tunica albuginea • cortex (Cumulus oophorus, Stroma) • Medulla
Fallopian tubes	Isthmus • Ampulla • Infundibulum • Fimbria
Ligaments	Broad (components: Mesovarium, Mesosalpinx, Mesometrium contents: Round of uterus, Proper of ovary) • Suspensory of ovary • Cardinal
Uterus	cervix/neck (External orifice - Canal of the cervix, Internal orifice) • corpus/body (Cavity of the body, Fundus) • layers (Endometrium, Myometrium, Perimetrium)
Vulva/mons pubis	Labium: commissures (Anterior • Posterior) • Frenulum labiorum pudendi • Labia majora • Cleft of venus • Labia minora • Vulval vestibule • interlabial sulci Clitoris: Vestibular bulbs • Clitoral crura • Corpus cavernosa • Clitoral glans (Frenulum, Hood) Vagina: vestibular glands/ducts (Bartholin's glands/Bartholin's ducts, Skene's glands/Skene's ducts) • Fossa of vestibule of vagina • Vaginal fornix • Hymen • Orifice
Vestiges	Wolffian (Gartner's duct, Epoophoron, Paroöphoron) • Canal of Nuck
Other	G-spot • Urethral sponge